Evidence map›Paper›PMID 41255659›Full record

ReviewWorld journal of clinical pediatrics2025

Research on gamma globulin unresponsive Kawasaki disease: A review.

Zu-Chuang Wu, Yan Pan

Abstract readReview
In one paragraph

Review in World journal of clinical pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Zu-Chuang WuDepartment of Pediatrics, The First Affiliated Hospital of Yangtze University, Jingzhou 434000, Hubei Province, China.
Yan PanDepartment of Pediatrics, The First Affiliated Hospital of Yangtze University, Jingzhou 434000, Hubei Province, China. woshipanyan@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kawasaki disease (KD) is an acute, self-limited systemic vasculitis that primarily affects children. Treating nonresponding KD with intravenous immunoglobulin (IVIG) presents numerous challenges. This article comprehensively reviews the basic theory, clinical manifestations and diagnosis, treatment strategies, disputes and challenges, historical evolution and current situation, and future research directions of immunoglobulin unresponsive KD. In terms of basic theory, the epidemiological characteristics of KD, the mechanism of IVIG action, and the pathophysiological mechanism of the nonresponsive type are elaborated. In the clinical manifestation and diagnosis section, symptoms, diagnostic criteria, and imaging applications are analyzed. The treatment strategy encompasses drug, nondrug and individualized therapy. Controversies and challenges focus on diagnostic difficulties, treatment disputes, and long-term prognosis research. The historical evolution and current situation review the changes in treatment strategies and the current state of affairs. Future research directions anticipate the role of new therapeutic drug research and development, breakthroughs in basic research, and international cooperation, aiming to provide a comprehensive reference for research and clinical practice in this field.

Indexed as

BiomarkersCoronary artery lesionsImmunomodulationIntravenous immunoglobulin resistanceKawasaki disease

Identifiers

PMID41255659
PMCPMC12620805

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.