ReviewTherapeutic advances in ophthalmology
Neonatal retinal hemorrhage and retinopathy of prematurity: a critical review of current practices and future directions.
Review in Therapeutic advances in ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A Potential Gut-Retina Axis in Retinopathy of Prematurity: Emerging Perspectives on Microbiome-Mediated Modulation of the IGF-1-VEGF Pathway.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neonatal retinal hemorrhage (RH) and retinopathy of prematurity (ROP) are significant causes of visual impairment in preterm infants, necessitating effective diagnostic and therapeutic strategies. This review synthesizes current approaches to RH and ROP management, highlighting their limitations and the critical need for standardized diagnostic criteria. Indirect ophthalmoscopy, while accessible, suffers from subjective variability, whereas wide-field digital retinal imaging, despite superior visualization, is limited by cost and training requirements. Vaginal delivery and prematurity-related factors, such as fragile retinal vasculature and neonatal complications (e.g., sepsis and hyperbilirubinemia), significantly increase RH and ROP risk, with severe RH correlating with ROP progression. Advances in digital retinal imaging and artificial intelligence (AI) offer promising solutions for early detection, enabling timely interventions such as anti-VEGF therapy to improve visual outcomes. Future directions include developing universal diagnostic standards, exploring novel treatments such as probiotics, and leveraging technologies such as optical coherence tomography. Enhanced screening programs, collaborative research, and public awareness are essential to optimize RH and ROP management, ultimately improving long-term visual prognosis for affected infants.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.