ReviewFrontiers in neuroscience2025
Brain organoids: a new paradigm for studying human neuropsychiatric disorders.
Review in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Transforming Brain Organoids Into Functional Platforms: Convergence of Engineering, Imaging, AI, and Ethics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Nutrition as a systems regulator of brain aging trajectories.Frontiers in molecular neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding human brain development and dysfunction is a major goal in neurobiology. Compared with traditional 2D models and animal models, brain organoids technology based on induced pluripotent stem cell (iPSC) constructs can more accurately recapitulate the developmental process of the human brain and simulate the characteristic phenotypes of neurological diseases in recent years. This technology is expected to change our understanding of human brain development, while providing a fresh perspective on elucidating the pathogenesis of inherited and acquired brain diseases. This article reviews the development and recent advances in brain organoids, explores their use in neuropsychiatric disorders, from neurodevelopmental to neurodegenerative and psychiatric diseases, while also outlining the challenges facing the technology. We conclude that these advances not only enhance our understanding of human-specific brain development and disease mechanisms, but also accelerate the translation of brain organoid technology into personalized medicine and drug discovery.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.