ArticleFrontiers in neuroscience2025
Comparative validation of automated perfusion analysis software for ischemic penumbra estimation and EVT decision-making.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Role of Artificial Intelligence in Acute Ischemic Stroke Care: A Narrative Review.Missouri medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: While computed tomography perfusion is widely used in acute stroke imaging, magnetic resonance perfusion-weighted imaging (PWI) offers superior spatial resolution and tissue specificity, particularly when combined with diffusion-weighted imaging (DWI). However, no prior study has systematically compared automated PWI analysis platforms. This study aims to evaluate the performance of a newly developed software (JLK PWI) against the established RAPID platform in terms of volumetric agreement and clinical decision concordance. Methods: This retrospective multicenter study included 299 patients with acute ischemic stroke who underwent PWI within 24 h of symptom onset. Volumetric agreement between RAPID and JLK PWI was assessed using concordance correlation coefficients (CCC), Bland-Altman plots, and Pearson correlations. Agreement in endovascular therapy (EVT) eligibility was evaluated using Cohen's kappa based on DAWN and DEFUSE-3 criteria. Results: The mean age was 70.9 years, 55.9% were male, and the median NIHSS score was 11 (IQR 5-17). The median time from the last known well to PWI was 6.0 h. JLK PWI showed excellent agreement with RAPID for ischemic core (CCC = 0.87; Conclusion: JLK PWI demonstrates high technical and clinical concordance with RAPID, supporting its use as a reliable alternative for MRI-based perfusion analysis in acute stroke care.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.