ArticleFrontiers in neuroscience2025
Neuroimaging and molecular mechanism of action of Cang-ai volatile oil in the treatment of vascular cognitive impairment.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
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7 authors.
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Abstract
Background: Cangai volatile oil (CAVO), as a traditional Chinese medicinal volatile oil, has been applied for its neuroprotective effects in conditions such as depression. Objective: To investigate whether CAVO can improve brain cognitive function in rats with vascular cognitive impairment using 7T high-field functional magnetic resonance imaging and molecular biology. Method: CAVO treatment was administered in a rat model of vascular dementia induced by bilateral permanent occlusion of the common carotid arteries (2 VO). The water maze was employed for behavioral assessment, while magnetic resonance imaging examined alterations in local homogeneity, low-frequency amplitude, and functional connectivity within the rat brain. Protein expression of inflammatory factors (NLRP3), apoptotic proteins (BAX, Bcl-2), and endoplasmic reticulum stress proteins (CHOP, PERK, GRP78) in the rat hippocampus was analyzed using Western blotting and PCR. Results: CAVO enhances functional connectivity strength in regions including the cingulate cortex-piriform cortex and anterior cingulate cortex-hypothalamus in VCI rats ( Conclusion: This study demonstrates that CAVO therapy reduces inflammatory responses in brain regions of VCI rats, decreases apoptosis and necrosis, protects neurons in affected areas, and simultaneously enhances functional connectivity strength between brain regions in VCI rats, thereby exerting a cognitive-improving effect on VCI.
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