ArticleResearch square2025
Beyond BRCA deficiency: Clinical and molecular predictors of survival in patients with BRCA-deficient tubo-ovarian high-grade serous carcinoma.
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Authors and funding
148 authors.
Dale GarsedPeter MacCallum Cancer Centre.ORCID 0000-0003-1223-0121
Tibor ZwimpferPeter MacCallum Cancer Centre.
Sian FeredayPeter MacCallum Cancer Centre.ORCID 0000-0002-8559-8579
Ahwan PandeyPeter MacCallum Cancer Centre.ORCID 0000-0003-2238-1054
Dinuka AriyaratnePeter MacCallum Cancer Centre.ORCID 0000-0001-5704-9030
Madawa JayawardanaPeter MacCallum Cancer Centre.
Laura TwomeyPeter MacCallum Cancer Centre.
Céline LaumontDeeley Research Centre, BC Cancer.
Catherine KennedyORCID 0000-0002-4465-5784
Adelyn BolithonSchool of Clinical Medicine, UNSW Medicine and Health, University of NSW Sydney.
Nicola MeagherAdult Cancer Program, Lowy Cancer Research Centre, University of NSW Sydney.
Katy MilneUniversity of British Columbia.ORCID 0000-0001-5616-1821
Phineas HamiltonBC Cancer.
Jennifer AlsopDepartment of Oncology, University of Cambridge.
Antonis AntoniouUniversity of Cambridge.
George Au-YeungPeter MacCallum Cancer Centre.
Matthias BeckmannUniversity Breast Center University Hospital Erlangen.
Amy Berrington de GonzalezNational Cancer Institute, NIH, DHHS.ORCID 0000-0002-7332-8387
Christiani BisinottoDepartment of Gynecology and Obstetrics, Ribeirão Preto Medical School, University of São Paulo.
Freya BlomeInstitute of Pathology and Neuropathology, Tuebingen University Hospital.ORCID 0009-0003-0866-7029
Clara BodelonDepartment of Population Science, American Cancer Society, Atlanta.ORCID 0000-0002-6578-2678
Jessica BorosCentre for Cancer Research, The Westmead Institute for Medical Research, Sydney.
Alison BrandWestmead Hospital.
Michael CarneyUniversity of Hawaii, Cancer Research Center.
Alicia Cazorla-JimenezPathology Department, Fundación Jiménez Díaz. Madrid.
Derek ChiuUniversity of British Columbia.
Elizabeth ChristiePeter MacCallum Cancer Centre.ORCID 0000-0002-9959-7024
Anita Chudecka-GlazDepartment of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University.
Penny CoulsonDivision of Genetics and Epidemiology, The Institute of Cancer Research, London.
Kara Cushing-HaugenProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center.
Cezary CybulskiPomeranian Medical School.
Kathleen DarcyGynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center.
Cath DavidGynaecological Cancer Centre, Royal Hospital for Women, Randwick.
Trent DavidsonNSW Health Pathology, Prince of Wales Hospital. Sydney.
Arif EkiciFAU-Uniklinikum Erlangen.ORCID 0000-0001-6099-7066
Esther ElishaevDepartment of Pathology, University of Pittsburgh School of Medicine.
Julius EmonsDepartment of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg. University Hospital Erlangen.
Tobias EnglerDepartment of Women's Health, Tuebingen University Hospital.
Rhonda FarrellFaculty of Medicine and Health, The University of Sydney.
Anna FischerInstitute of Pathology and Neuropathology, Tuebingen University Hospital.
Montserrat Garcia-ClosasNational Cancer Institute.
Aleksandra Gentry-MaharajUCL EGA Institute for Women's Health.
Prafull GhatageDepartment of Oncology, Division of Gynecologic Oncology, Cumming School of Medicine, University of Calgary.ORCID 0000-0002-2371-0844
Rosalind GlasspoolBeatson West of Scotland Cancer Centre and School of Cancer Sciences, University of Glasgow.
Philipp HarterDepartment of Gynecology and Gynecologic Oncology, Evangelische Kliniken Essen-Mitte.
Andreas HartkopfDepartment of Women's Health, Tuebingen University Hospital.
Arndt HartmannFAU-Uniklinikum Erlangen.
Sebastian HeikausCenter for Pathology, Evangelische Kliniken Essen-Mitte.
Brenda HernandezUniversity of Hawai'i Cancer Center.
Anusha HettiaratchiThe Health Precincts Biobank, UNSW Biospecimen Services, Mark Wainwright Analytical Centre.ORCID 0000-0002-5928-2300
Sabine HeubleinDepartment of Obstetrics and Gynecology, University Hospital Heidelberg.
David HuntsmanThe University of British Columbia.
Mercedes Jimenez-LinanDepartment of Histopathology, Addenbrooke's Hospital, Cambridge.
Michael JonesORCID 0000-0001-7479-3451
Eunjoung KangDepartment of Surgery, Seoul National University Bundang Hospital.
Ewa KaznowskaDepartment of Pathology, Institute of Medical Sciences, Medical College of Rzeszow University.
Tomasz KluzDepartment of Gynecology, Gynecology Oncology and Obstetrics, Institute of Medical Sciences, Medical College of Rzeszów University.
Felix KommossUniversity Hospital Heidelberg.ORCID 0000-0003-0876-9087
Gottfried E KonecnyUniversity of California at Los Angeles.
Rutgerus KruitwagenGROW, School for Oncology and Developmental Biology, Maastricht university, 6229 ER Maastricht.
Jessica KwonDepartment of Obstetrics and Gynecology, University of British Columbia.
Diether LambrechtsKU Leuven & VIB.ORCID 0000-0002-3429-302X
Cheng-Han LeeUniversity of Alberta.ORCID 0000-0003-2094-1222
Jenny LesterUniversity of California at Los Angeles.
Samuel LeungBritish Columbia's Gynecological Cancer Research Team OVCARE, University of British Columbia, BC Cancer, and Vancouver General Hospital.
Yee LeungDepartment of Gynaecological Oncology, King Edward Memorial Hospital, Subiaco.ORCID 0000-0003-0349-8652
Anna LinderDepartment of Obstetrics and Gynecology, Institute of Clinical Science, Sahlgrenska Center for Cancer Research, University of Gothenburg.ORCID 0000-0002-9444-1346
Jolanta LissowskaDepartment of Cancer Epidemiology and Prevention, M Sklodowska-Curie National Research Oncology Institute.
Liselore LoverixDivision of Gynecologic Oncology, Department of Gynecology and Obstetrics. Leuven Cancer Institute.
Jan LubińskiPomeranian Medical University.
Constantina MateoiuDepartment of Pathology, University of Gothenburg.
Lain McNeishImperial College London.ORCID 0000-0002-9387-7586
Malak MoubarakDepartment of Gynecology and Gynecologic Oncology, Evangelische Kliniken Essen-Mitte.
Gregg NelsonDepartment of Oncology, Division of Gynecologic Oncology, Cumming School of Medicine, University of Calgary.ORCID 0000-0002-8177-1098
Nikilyn NevinsCentre for Cancer Research, The Westmead Institute for Medical Research, Sydney.ORCID 0000-0002-5744-4281
Alexander OlawaiyeDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine.
Siel OlbrechtDivision of Gynecologic Oncology, Department of Gynecology and Obstetrics. Leuven Cancer Institute.
Sandra OrsulicDavid Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles.
Ana OsorioGenetics Service, Fundación Jiménez Díaz University Hospital and Health Research Institute, Universidad Autónoma de Madrid IIS-FJD.
Carmel QuinnThe Health Precincts Biobank, UNSW Biospecimen Services, Mark Wainwright Analytical Centre.
Ganendra Raj MohanDepartment of Gynaecological Oncology, King Edward Memorial Hospital, Subiaco.
Isabelle Ray-CoquardCentre Leon Bérard.ORCID 0000-0003-2472-8306
Cristina Rodriguez-AntonaCentre for Biomedical Network Research on Rare Diseases CIBERER, Instituto de Salud Carlos III.
Patricia RoxburghSchool of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow.ORCID 0000-0001-9869-591X
Matthias RübnerFriedrich-Alexander University of Erlangen-Nuremberg.
Stuart SalfingerDepartment of Gynaecological Oncology, St John of God Subiaco Hospital, Subiaco.
Spinder SamraCentre for Cancer Research, The Westmead Institute for Medical Research, Sydney.
Minouk SchoemakerDivision of Genetics and Epidemiology, The Institute of Cancer Research, London.
Hans-Peter SinnInstitute of Pathology, Heidelberg University Hospital.
Gabe SonkeThe Netherlands Cancer Institute.
Linda SteeleBeckman Research Institute of City of Hope.
Colin StewartKing Edward Memorial Hospital.
Aline TalhoukBritish Columbia's Gynecological Cancer Research Team OVCARE, University of British Columbia, BC Cancer, and Vancouver General Hospital.
Adeline TanDivision of Obstetrics and Gynaecology, Medical School, University of Western Australia.
Christopher TarneyGynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center.
Sarah TaylorDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine.
Koen Van de VijverGhent University Hospital.ORCID 0000-0002-2026-9790
Maaike Avan der AaDepartment of Research and Development, Netherlands Comprehensive Cancer Organization (IKNL), 3511 DT Utrecht.
Toon Van GorpDivision of Gynaecological Oncology, Leuven Cancer Institute, University Hospital Leuven and KU Leuven.
Els Van NieuwenhuysenUniversity Hospitals Leuven.
Lilian van WagensveldThe Netherlands Cancer Institute.
Andrea Wahner-HendricksonDepartment of Oncology, Mayo Clinic.
Christina WalterDepartment of Women's Health, Tuebingen University Hospital.
Chen WangMayo Clinic.ORCID 0000-0003-2638-3081
Julia WelzDepartment of Gynecology and Gynecologic Oncology, Evangelische Kliniken Essen-Mitte.
Nicolas WentzensenNational Cancer Institute.ORCID 0000-0003-1251-0836
Lynne WilkensUniversity of Hawaii Cancer Center.
Stacey WinhamMayo Clinic.ORCID 0000-0002-8492-9102
Boris WinterhoffDivision of Gynecologic Oncology, University of Minnesota, Minneapolis, MN 55455, USA.
Michael AnglesioBritish Columbia's Gynecological Cancer Research (OVCARE) Program, University of British Columbia, Vancouver General Hospital, and BC Cancer.ORCID 0000-0003-1639-5003
Andrew BerchuckDuke University Medical Center.
Francisco Candido do ReisDepartment of Gynecology and Obstetrics, Ribeirão Preto Medical School, University of São Paulo.
Paul CohenDepartment of Gynaecological Oncology, King Edward Memorial Hospital, Subiaco.ORCID 0000-0002-4860-9232
Thomas ConradsWalter Reed National Military Medical Center.ORCID 0000-0003-4742-3281
Philip CroweSchool of Clinical Medicine, UNSW Medicine and Health, University of NSW Sydney.
Jennifer DohertyHuntsman Cancer Institute, Department of Population Health Sciences, University of Utah.
Peter FaschingUniversity Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN, Friedrich Alexander University Erlangen-Nuremberg.ORCID 0000-0003-4885-8471
Renée FortnerDivision of Cancer Epidemiology, German Cancer Research Center DKFZ, Heidelberg.
Maria GarciaGenomic Biomarkers and Precision Oncology Group, Sols-Morreale Biomedical Research Institute IIBM, Consejo Superior de Investigaciones Cientficas & Universidad Autónoma de Madrid CSIC-UAM.
Simon GaytherCenter for Inherited Oncogenesis, Department of Medicine, UT Health San Antonio, San Antonio, TX 78229, USA.
Marc GoodmanCSHS.
Jacek GronwaldPomeranian Medical School.
Holly HarrisProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.
Florian HeitzKliniken Essen-Mitte.
Hugo HorlingsThe Netherlands Cancer Institute.ORCID 0000-0003-4782-8828
Beth KarlanDavid Geffen School of Medicine at UCLA.ORCID 0000-0002-9451-2933
Linda KelemenCommunicable Disease Epidemiology Section, South Carolina Department of Public Health.
George MaxwellWomen's Service Line, Inova Health System.
Usha MenonUniversity College London.ORCID 0000-0003-3708-1732
Francesmary ModugnoDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine.
Susan NeuhausenBeckman Research Institute of City of Hope.ORCID 0000-0001-5053-0390
Joellen SchildkrautDepartment of Epidemiology, Rollins School of Public Health, Emory University.
Annette StaeblerInstitute of Pathology and Neuropathology, Tuebingen University Hospital.
Karin SundfeldtDepartment of Obstetrics and Gynecology, Institute of Clinical Science, Sahlgrenska Center for Cancer Research, University of Gothenburg.
Anthony SwedlowDivision of Genetics and Epidemiology, The Institute of Cancer Research, London.
Ignace VergoteDivision of Gynecologic Oncology, Department of Gynecology and Obstetrics. Leuven Cancer Institute.
Anna WuUniversity of Southern California.
James BrentonCancer Research UK Cambridge Institute, University of Cambridge.ORCID 0000-0002-5738-6683
Paul PharoahCedars-Sinai Medical Center.ORCID 0000-0001-8494-732X
Celeste PearceUniversity of Michigan-Ann Arbor.
Malcolm Pikemskcc.
Ellen GoodeMayo Clinic.ORCID 0000-0002-9094-8326
Susan RamusUniversity of New South Wales Sydney.ORCID 0000-0003-0005-7798
Martin KöbelUniversity of Calgary.ORCID 0000-0002-6615-2037
Brad NelsonUniversity of British Columbia.ORCID 0000-0002-4445-5539
Anna DeFazioUniversity of Sydney, Westmead Institute for Medical Research.ORCID 0000-0003-0057-4744
Michael FriedlanderUniversity of South Wales.ORCID 0000-0003-3090-795X
David BowtellPeter Mac Callum Cancer Center.
Funding
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3MUse of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI SCOTT H KAUFMANN · 2009 to 2026
$37.0MWITHIN SUBJ VARIABILITY IN MEASUREMENTS DRUG METABOL ENZYMES IN HLTY SUBJM01RR000056 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEVINE, ARTHUR S · 1985 to 2006
$29.2MRelating Molecular Subgroups of Endometriosis-Associated Ovarian Cancers to Survival and RiskR01CA248288 · NCI · MAYO CLINIC ROCHESTER · PI Stacey J Winham · 2021 to 2026
$4.8MIdentifying Prognostic Markers and Therapeutic Targets for Serous Ovarian CancerR01CA172404 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RAMUS, SUSAN J · 2013 to 2017
$2.9MInflammation and Ovarian CancerR01CA095023 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUNKER, CLAREANN H. · 2003 to 2008
$2.7MEpidemiologic factors and survival by molecular subtypes of ovarian cancerR01CA168758 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DOHERTY, JENNIFER A., ROSSING, MARY ANNE · 2013 to 2016
$2.6MOVARIAN CANCER RISK AND SURVIVAL IN BRCA CARRIERSK07CA080668 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MODUGNO, FRANCESMARY · 2000 to 2005
$661kMulti-omic Predictive Markers for Ovarian Cancer Therapy Response and OutcomesR21CA267050 · NCI · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI MODUGNO, FRANCESMARY · 2022 to 2023
$408kNCI NIH HHS K07 CA080668NCI NIH HHS P30 CA015083NCI NIH HHS P50 CA136393NCI NIH HHS R01 CA095023NCI NIH HHS R01 CA168758NCI NIH HHS R01 CA172404NCI NIH HHS R01 CA248288NCI NIH HHS R21 CA267050NCRR NIH HHS M01 RR000056
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