Evidence map›Paper›PMID 41256152›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Genetic Diversity of the Malaria Vaccine Candidate PfRIPR in a High Transmission Region of Senegal.

Megha Nair, Giselle Geering, Alyssa Agarwal, Rebecca Li, Yujie Qiao, Qin Xiao, Mariama N Pouye, Laty G Thiam, Aboubacar Ba, Kelly A Hagadorn and 15 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Megha NairDepartment of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, USA.ORCID 0009-0008-2499-8860
Giselle GeeringDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Alyssa AgarwalDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.ORCID 0000-0001-7276-1034
Rebecca LiDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Yujie QiaoAaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Qin XiaoAaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Mariama N PouyeG4 Malaria Experimental Genetic Approaches & Vaccines, Pôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal.ORCID 0000-0001-9067-2713
Laty G ThiamG4 Malaria Experimental Genetic Approaches & Vaccines, Pôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal.ORCID 0000-0001-7086-4726
Aboubacar BaG4 Malaria Experimental Genetic Approaches & Vaccines, Pôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal.ORCID 0000-0003-2351-2394
Kelly A HagadornDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.ORCID 0000-0001-7200-7023
Awa CisseDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Noemi GuerraDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.ORCID 0009-0008-8472-7130
Yome TawaldemedhenDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.ORCID 0009-0007-6172-6971
Khadidiatou MangouG4 Malaria Experimental Genetic Approaches & Vaccines, Pôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal.
Adam J MooreDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.ORCID 0000-0001-8961-1737
Fatoumata DialloG4 Malaria Experimental Genetic Approaches & Vaccines, Pôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal.
Seynabou D SeneG4 Malaria Experimental Genetic Approaches & Vaccines, Pôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal.ORCID 0000-0003-2812-0680
Bacary D SadioPôle Virologie, Institut Pasteur de Dakar, Dakar, Senegal.ORCID 0009-0005-3648-3045
Elizabeth ZhangDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Lawrence ShapiroAaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.ORCID 0000-0001-9943-8819
Saurabh D PatelZuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.ORCID 0000-0002-5738-3175
Alassane MbengueG4 Malaria Experimental Genetic Approaches & Vaccines, Pôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal.ORCID 0000-0002-4210-6167
Ines Vigan-WomasPôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal.
Zizhang ShengAaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.ORCID 0000-0002-3253-3309
Amy K BeiDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.ORCID 0000-0003-1159-760X

Funding

Evaluating the Functional Impact of Genetic Diversity on Malaria Vaccine CandidatesR01AI168238 · NIAID · YALE UNIVERSITY · PI Amy Kristine Bei · 2022 to 2026
$3.5M
Quick and Accurate Measurements of HIV Broadly Neutralizing Antibody SusceptibilityR61AI176583 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHENG, ZIZHANG, WU, XUELING · 2023 to 2025
$3.0M
Employing genetic and genomic surveillance to reveal mechanisms of malaria parasite persistenceK01TW010496 · FIC · YALE UNIVERSITY · PI BEI, AMY KRISTINE · 2016 to 2021
$754k
FIC NIH HHS K01 TW010496NIAID NIH HHS R01 AI168238NIAID NIH HHS R61 AI176583Wellcome Trust
6 · The paper itself

Abstract

RH5-Interacting Protein (RIPR) is essential for the invasion of

Identifiers

PMID41256152
PMCPMC12622123

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.