Evidence map›Paper›PMID 41256175›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Validation and context-dependent effects of a prostate cancer polygenic risk score in the All of Us Research Program.

Shuyan Cheng, Austin Hammermeister Suger, Louisa B Goss, Jiachen Zhang, Harriett Fuller, Boya Guo, Sara Lindström, Burcu F Darst

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Shuyan ChengSchool of Public Health, University of Washington, Seattle, WA, USA.ORCID 0009-0006-0559-4073
Austin Hammermeister SugerSchool of Public Health, University of Washington, Seattle, WA, USA.
Louisa B GossDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Jiachen ZhangSchool of Public Health, University of Washington, Seattle, WA, USA.
Harriett FullerDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Boya GuoDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-8508-4084
Sara LindströmSchool of Public Health, University of Washington, Seattle, WA, USA.
Burcu F DarstSchool of Public Health, University of Washington, Seattle, WA, USA.

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4M
TRANSCRIPTOME AND PROTEOME STRATIFICATION OF PROSTATE ADENOCARCINOMA PHENOTYPESP50CA097186 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETER S NELSON · 2002 to 2026
$58.1M
Leveraging Prospective Cancer Epidemiology Cohorts and Novel Methods to Improve Polygenic Risk ScoresU01CA261339 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fei Chen, David V Conti · 2021 to 2026
$5.2M
Integrating Genomics and Metabolomics to Develop Predictive Models of Prostate Cancer in Multiethnic MenR00CA246063 · NCI · FRED HUTCHINSON CANCER CENTER · PI DARST, BURCU FRANCES · 2022 to 2024
$830k
Germline Genetics and Risk of Prostate Cancer in Diverse Populations from the All of Us ProgramR03CA287235 · NCI · FRED HUTCHINSON CANCER CENTER · PI DARST, BURCU FRANCES · 2023 to 2024
$368k
NCI NIH HHS P30 CA015704NCI NIH HHS P50 CA097186NCI NIH HHS R00 CA246063NCI NIH HHS R03 CA287235NCI NIH HHS U01 CA261339
6 · The paper itself

Abstract

Polygenic risk scores (PRSs) have demonstrated strong potential for improving prostate cancer risk stratification. However, it is unknown whether the clinical utility of prostate cancer PRS vary by demographic, lifestyle, and socioeconomic factors. We validated a previously developed multi-ancestry PRS of 451 prostate cancer risk variants and evaluated context-dependent effects using genetic and clinical data from the diverse All of Us Research Program, including 7,577 cases and 90,608 controls across six genetic ancestry groups. In ancestry-stratified testing, the PRS showed strong associations with prostate cancer risk, with odds ratios (ORs) per standard deviation (SD) increase ranging from 1.61 (95% CI=1.02-2.64, P=0.05) in Middle Eastern to 2.19 (95% CI=1.98-2.42, P=2.2×10

Indexed as

context-dependent effectslarge-scale biobanksphenome-wide association studyPolygenic risk scoreprostate cancerrisk modeling

Identifiers

PMID41256175
PMCPMC12622063

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.