Evidence map›Paper›PMID 41256193›Full record

ReviewSmall science2025

Nanoscale Analysis beyond Imaging by Atomic Force Microscopy: Molecular Perspectives on Oncology and Neurodegeneration.

Carlos Marcuello, KeeSiang Lim, Giacomo Nisini, Vadim S Pokrovsky, João Conde, Francesco Simone Ruggeri

Abstract readReview
In one paragraph

Review in Small science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Pancancer Analysis and the Oncogenic Role ofInternational journal of molecular sciences · 2026
    Article
  5. Neurotransmitter Systems in Alzheimer's Disease.Current issues in molecular biology · 2026
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Circulating Tumor Cells for the Monitoring of Lung Cancer Therapies.International journal of molecular sciences · 2025
    Review
  17. Article
  18. Review
  19. Quantitative ctDNA Profiling ofInternational journal of molecular sciences · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carlos MarcuelloLaboratorio de Microscopias Avanzadas (LMA) Universidad de Zaragoza Zaragoza 50018 Spain.ORCID https://orcid.org/0000-0003-3459-8605
KeeSiang LimWPI-Nano Life Science Institute Kanazawa University Ishikawa 920-1192 Japan.
Giacomo NisiniPhysical Chemistry and Soft Matter Wageningen University Stippeneng 4 6708 WE Wageningen Netherlands.
Vadim S PokrovskyPatrice Lumumba People's Friendship University 117198 Moscow Russia.ORCID https://orcid.org/0000-0003-4006-9320
João CondeComprehensive Health Research Centre (CHRC) Faculdade de Ciências Médicas (FCM) Universidade Nova de Lisboa 1099-085 Lisboa Portugal.
Francesco Simone RuggeriPhysical Chemistry and Soft Matter Wageningen University Stippeneng 4 6708 WE Wageningen Netherlands.ORCID https://orcid.org/0000-0002-1232-1907

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanobiomedicine promises to revolutionize life quality and expectancy of patients with cognitive impairment and cancer malignancies, via unraveling key molecular processes related to their onset useful as biomarkers of disease to develop and improve the efficacy of therapies. However, it is still a challenge understanding and identifying these molecular mechanisms as biomarkers of disease, because of their high-level of polymorphism and nanoscale dimensions. Here, it provides a review work linking the potential and capabilities of atomic force microscopy (AFM) technologies in unraveling beyond imaging the common and hidden properties of transient and nanosized molecular processes in cancer and neurodegeneration. This study highlights the most prominent operational modes of AFM to achieve morphological, mechanical, and chemical characterization of the molecular processes leading to these diseases. Finally, it outlines the advantages of AFM compared with other techniques to guide newcomers and stakeholders toward potential future avenues opened by AFM methods in nanobiomedicine.

Indexed as

amyloidogenic proteinsatomic force microscopybiomolecular processescancer diseasesforce spectroscopynano‐chemical analysisneurodegeneration

Identifiers

PMID41256193
PMCPMC12622512

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.