Trial reportJournal of multidisciplinary healthcare2025
Efficacy of Fire Needle Therapy Combined with Doxycycline Hydrochloride in the Management of Moderate-to-Severe Acne Vulgaris: A Randomized Controlled Trial.
Trial report in Journal of multidisciplinary healthcare, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Fire needle therapy has shown promise in treating acne vulgaris (AV), improving facial lesions and patient quality of life. This study aims to investigate the effects of combining fire needle therapy with doxycycline hydrochloride tablets (DHT) on the Global Acne Grading System (GAGS), the échelle d'évaluation clinique des cicatrices d'acné (ECCA) grading scale, the Dermatology Life Quality Index (DLQI), and the serum levels of inflammatory factors interleukin-17 (IL-17), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in patients with moderate-to-severe AV. Methods: 70 patients with moderate-to-severe AV were randomly assigned to the control group (n=35) to receive oral DHT treatment once a day and the intervention group (n=35) to be treated with fire needle therapy on the basis of DHT once a week. The total treatment duration for both groups was 8 weeks. Therapeutic efficacy was evaluated at the 4-week and 8-week marks. The primary outcome measure evaluated was the GAGS score. The secondary outcome measures included the ECCA score, the DLQI score, and the serum levels of the inflammatory factors IL-17, TNF-α, and IL-6. Results: Compared to baseline data, both groups exhibited marked improvements in skin lesions at both the 4-week and 8-week treatment marks. Significant reductions were observed in the GAGS, ECCA, and DLQI scores, as well as in the serum levels of the inflammatory factors IL-17, TNF-α, and IL-6. Notably, the intervention group demonstrated significantly greater improvements than the control group at both the 4-week and 8-week assessments. Conclusion: An 8-week regimen of fire needle therapy combined with DHT improved lesion severity, scar symptoms, quality of life, and serum inflammatory cytokine levels in patients with moderate-to-severe AV compared to DHT monotherapy.
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