ArticlebioRxiv : the preprint server for biology2025
Degeneration and Impaired Resilience of Skull Bone and Hematopoietic Bone Marrow.
Yang Yang, Yonggang Fan, Sanyam Jain, Zhangfan Ding, Hanyu Liu, Allison L Horenberg, Haiyang Sun, Mara Sophie Killer, Abhishek Chandra, Rinkoo Dalan and 12 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
22 authors.
Yang YangTissue and Tumor Microenvironments Lab, Cancer Discovery and Regenerative Medicine Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Yonggang FanTissue and Tumor Microenvironments Lab, Cancer Discovery and Regenerative Medicine Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Sanyam JainTissue and Tumor Microenvironments Lab, Cancer Discovery and Regenerative Medicine Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Zhangfan DingTissue and Tumor Microenvironments Lab, Cancer Discovery and Regenerative Medicine Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.ORCID 0000-0002-1107-8861 Hanyu LiuTissue and Tumor Microenvironments Lab, Cancer Discovery and Regenerative Medicine Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Allison L HorenbergDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Haiyang SunState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Mara Sophie KillerCancer Discovery and Regenerative Medicine Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Abhishek ChandraDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-9735-9436 Rinkoo DalanLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.ORCID 0000-0001-9769-2696 Manju ChandranOsteoporosis and Bone Metabolism Unit, Department of Endocrinology, Singapore General Hospital, Singapore, Singapore.ORCID 0000-0001-9119-8443 Junyu ChenTissue and Tumor Microenvironments Lab, Cancer Discovery and Regenerative Medicine Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.ORCID 0000-0003-1717-5782 Navin Kumar VermaLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.ORCID 0000-0002-5940-6633 Christine CheungLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.ORCID 0000-0001-7127-9107 Makrand V RisbudDepartment of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0003-3913-0649 Aline BozecDepartment of Internal Medicine 3 - Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.ORCID 0000-0001-8174-2118 Kristijan RamadanThe MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.ORCID 0000-0001-5522-021X Martine Cohen-SolalDepartment of Rheumatology and Reference Center for Rare Bone Diseases, Hospital Lariboisière, Paris, France.ORCID 0000-0002-8582-8258 Warren L GraysonDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-6099-6469 Saravana K RamasamyLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.ORCID 0000-0003-2658-2945 Anjali P KusumbeTissue and Tumor Microenvironments Lab, Cancer Discovery and Regenerative Medicine Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.ORCID 0000-0002-1911-5495 Funding
Role of HIF-1 in Intervertebral Disc FunctionR01AR055655 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI RISBUD, MAKARAND V · 2008 to 2023
$6.1MTargeting cell senescence in a novel model of spontaneous disc degenerationR01AG073349 · NIA · THOMAS JEFFERSON UNIVERSITY · PI RISBUD, MAKARAND V · 2021 to 2025
$3.0MOxygen-eluting scaffolds for cranial bone regenerationR01DE027957 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI GRAYSON, WARREN L, PATHAK, ARVIND P · 2019 to 2023
$2.4MThe role of endogenous low molecular weight mineralization inhibitors in spine healthR01AR082460 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI Makarand V Risbud, Koen van de Wetering · 2024 to 2026
$1.9MRole of p21 positive senescent cells in radiation-induced skeletal injury and repairR01AG082681 · NIA · MAYO CLINIC ROCHESTER · PI Abhishek Chandra · 2023 to 2026
$1.6MInvestigating neuroskeletal interactions in non-healing calvarial defect injuriesF31DE033910 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI HORENBERG, ALLISON · 2024 to 2024
$50kNIAMS NIH HHS R01 AR055655NIAMS NIH HHS R01 AR082460NIA NIH HHS R01 AG073349NIA NIH HHS R01 AG082681NIDCR NIH HHS F31 DE033910NIDCR NIH HHS R01 DE027957
6 · The paper itselfAbstract
Bone marrow health is central to transplantations, blood formation, and cancer progression. However, the bone marrow niche deteriorates with age, impairing haematopoietic stem cell function. Contrary to a recent report
Indexed as
ageingblood vesselsbone marrowhaematopoieticskull
Identifiers
PMID41256358
PMCPMC12621781
What Socratic holds
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