Evidence map›Paper›PMID 41256359›Full record

ArticlebioRxiv : the preprint server for biology2025

Essential Role for Trf2 in Cardiac Development and Function.

Ali Hakim Shoushtari, Aysenur Danis, Michael Wayne Stoner, Jeffrey Baust, Andrea Sebastiani, Paramesha Bugga, Janet R Manning, Bellina A S Mushala, Nisha Bhattarai, Imad Al Ghouleh and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Ali Hakim Shoushtari
Aysenur Danis
Michael Wayne Stoner
Jeffrey Baust
Andrea Sebastiani
Paramesha Bugga
Janet R Manning
Bellina A S Mushala
Nisha Bhattarai
Imad Al Ghouleh
Iain Scott
Maryam Sharifi-Sanjani

Funding

Endothelial Reprogramming in Pulmonary HypertensionR01HL148712 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AL GHOULEH, IMAD · 2019 to 2023
$1.9M
NHLBI NIH HHS R01 HL148712
6 · The paper itself

Abstract

Telomere Repeat-binding Factor 2 (Trf2) is essential for protecting our telomeres. While Trf2 global deletion is lethal, its role in organ-specific development, particularly in the heart, remains less understood. In this study, we investigated the role of Trf2 in cardiac development and function. Our studies reveal that cardiomyocyte (CM)-specific loss of Trf2 leads to profound defects in heart morphology, including impaired ventricular wall formation and compromised CM proliferation, concurrent with no CM telomere length attrition. Further,

Identifiers

PMID41256359
PMCPMC12621949

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.