Evidence map›Paper›PMID 41256378›Full record

ArticlebioRxiv : the preprint server for biology2025

Desmoglein-2 deficiency results in cardiac dysfunction by compromising both Z-disc- and intercalated disc-mediated mechanotransduction.

Maicon Landim-Vieira, Vivek P Jani, Emily Shiel, Hosna Rastegarpouyani, Morgan Engel, Flair Paradine, Ronnie Chastain, Waleed Farra, Weikang Ma, Christopher Toepfer and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maicon Landim-VieiraDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA.ORCID 0000-0002-6696-8888
Vivek P JaniDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Emily ShielDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA.
Hosna RastegarpouyaniInstitute of Molecular Biophysics, Florida State University, Tallahassee, Florida, USA.
Morgan EngelDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA.
Flair ParadineDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Ronnie ChastainDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA.
Waleed FarraDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA.
Weikang MaBioCAT, Department of Biology, Illinois Institute of Technology, Chicago, IL, USA.
Christopher ToepferDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
P Bryant ChaseDepartment of Biological Science, Florida State University, Tallahassee, FL, USA.
David A KassDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
J Renato PintoDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA.
Stephen P ChelkoDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA.

Funding

Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3M
The Biophysics Collaborative Access Team (User Training and Outreach)P30GM138395 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI THOMAS C IRVING · 2021 to 2026
$16.5M
NIGMS NIH HHS P30 GM124166NIGMS NIH HHS P30 GM138395
6 · The paper itself

Abstract

Desmoglein-2 (DSG2), a critical component of the cardiac desmosome and located at the cardiomyocyte-cardiomyocyte intercalated disc, is essential for cell-cell adhesion, cardiomyocyte mechanical stability, and electrical coupling between cells. However, its relative contribution in maintaining cardiac function at the sarcomere level remains unclear. Using 4-week-old (adolescent) and 16-week-old (adult) homozygous knock-in

Identifiers

PMID41256378
PMCPMC12621914

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.