ArticleJBMR plus2025
Directed vascularization in bone regeneration requires bone marrow reconstitution.
Article in JBMR plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Anatomical and biological reconstruction of traumatic complete burst fractures of the thoracolumbar vertebrae using pedicle fixation combined with stent-armed kyphoplasty and intracorporeal bone grafting: technique rationale, 7-year experience and clinical, imaging, and histological outcomes.Journal of spine surgery (Hong Kong) · 2026Article
- Smart and stimuli-responsive hydrogels for controlled exosome delivery in bone tissue engineering: from passive carriers to intelligent therapeutic platforms.Cell and tissue banking · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone has the unique ability to regenerate without scarring, yet the cellular dynamics and directional organization underlying this process, and how they are linked to marrow reconstitution, remain incompletely understood. To investigate these mechanisms, we developed a novel double osteotomy model in mice, involving transplantation of a 2-mm bone graft between genetically distinct fluorescent reporter lines (yellow fluorescent protein and red fluorescent protein). This approach enabled precise tracking of cellular migration and vascularization over 3, 7, and 14 d post-transplantation. Our findings revealed directed migration of host-derived proximal bone marrow cells into the graft, starting at day 3 and leading to complete host cell infiltration by day 14. CD146-positive blood vessels, mainly originating from the proximal host marrow, invaded the graft coinciding with graft marrow remodeling. Marrow disintegration within the graft occurred prior to vascular and cellular invasion, with subsequent reconstitution progressing from the proximal side. Flushing the graft marrow cavity prior to transplantation resulted in more extensive marrow niche formation by day 14 suggesting that marrow reconstitution can proceed more rapidly without the need for prior remodeling. This study introduces a new model to dissect the spatial and temporal coordination of cellular migration and vessel invasion during bone regeneration. Our results uncover the directional nature of healing and underscore the critical role of marrow reconstitution in guiding regenerative processes-insights that may inform surgical and biomaterial strategies to enhance bone repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.