ArticleFrontiers in psychiatry2025
Functional iron blockade in chronic stress and neurodivergence: a perspective on adaptive stress physiology.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The Relationship Between Trace Elements and Depression.Nutrients · 2026Review
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1 author.
Funding
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Abstract
Burnout and trauma are often framed as psychosocial conditions or as dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. Yet across more than two decades of clinical observation, I have repeatedly encountered a recurring metabolic signature that does not fit existing frameworks: persistent hyperferritinemia without hemochromatosis or overt inflammation, coexisting with low dehydroepiandrosterone-sulfate (DHEA-S) and preserved but gradually declining cortisol dynamics. This constellation is frequently observed in neurodivergent individuals and their families, with early signs already visible in childhood as mild anemia, elevated ferritin, low vitamin D, and behavioral hypervigilance. I propose that this pattern reflects a functional iron blockade (FIB), in which low-grade interleukin-6 signaling upregulates hepcidin, degrades ferroportin, and traps iron intracellularly. While protective against oxidative stress by reducing labile Fe²
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