ArticleERJ open research2025
Diuretic adherence in patients with pre-capillary pulmonary hypertension: insights from the PHARE study.
Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
14 authors.
Funding
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Abstract
Background: Supportive treatments, such as diuretics, play a critical role in managing pulmonary hypertension (PH). While low adherence to oral PH therapies worsens outcomes, the impact of diuretic adherence is less clear. This study aimed to determine diuretic adherence in patients managed for pre-capillary PH. Methods: This prospective, single-centre study, conducted from January 2022 to January 2024, evaluated medication adherence using the medication possession ratio (MPR) and a self-administered questionnaire (Girerd score). Factors contributing to low adherence and their potential association with serious clinical events were analysed. Results: Among the 220 patients included, 39% demonstrated low adherence to diuretics based on the MPR. According to the Girerd score, 28% of patients reported high adherence, 62% reported minor adherence issues and 10% reported low adherence to diuretics. Factors associated with low adherence measured by the MPR included younger age (<40 Conclusion: These findings suggest that low adherence to diuretics is frequent in PH and could be associated with worse outcomes. Future studies should assess whether detection of PH patients at risk of low adherence and subsequent targeted educational interventions may improve clinical outcomes.
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Registered trials
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