ReviewWorld journal of gastroenterology2025
Mechanisms of ferroptosis in primary hepatocellular carcinoma and progress of artificial intelligence-based predictive modeling in hepatocellular carcinoma.
Review in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Phenotypic Response Surfaces-Guided Optimization (PRS-OPT) of Propolis-Metformin-Regorafenib Combination Therapy for MASLD-Associated Hepatocellular Carcinoma.Oncology research · 2026Article
- The translational paradox of AI in hepatocellular carcinoma: from algorithmic over-engineering to real-world clinical utility.Frontiers in oncology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ferroptosis, an iron-dependent form of programmed cell death, has garnered significant attention in tumor research in recent years. Its core characteristics include aberrant accumulation of lipid peroxides and impairment of antioxidant defense mechanisms, such as dysfunction of glutathione peroxidase 4. These features are closely intertwined with the initiation, progression, and therapeutic resistance of hepatocellular carcinoma (HCC). This review presents a systematic overview of the fundamental molecular mechanisms underlying ferroptosis, encompassing iron metabolism, lipid metabolism, and the antioxidant system. Furthermore, it summarizes the potential applications of targeting ferroptosis in liver cancer treatment, including the mechanisms of action of anticancer agents (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.