Evidence map›Paper›PMID 41257286›Full record

ArticleMolecular therapy. Methods & clinical development2025

Preconditioning with StemRegenin 1 enhances human adipose stromal/stem cells proliferation, migration, and protection against antimycin A.

Jing Zhao, Bin Yu, Julie Fradette, Borhane Annabi, Maria Petropavlovskaia, Nicoletta Eliopoulos

Abstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jing ZhaoLady Davis Institute for Medical Research, SMBD-Jewish General Hospital, Montreal, QC H3T 1E2, Canada.
Bin YuLady Davis Institute for Medical Research, SMBD-Jewish General Hospital, Montreal, QC H3T 1E2, Canada.
Julie FradetteRegenerative Medicine Division, CHU de Quebec-Université Laval Research Center, Quebec, QC G1J 1Z4, Canada.
Borhane AnnabiLaboratoire d'Oncologie Moléculaire, Département de Chimie, Université du Québec à Montréal, Montreal, QC H2X 2J6, Canada.
Maria PetropavlovskaiaLady Davis Institute for Medical Research, SMBD-Jewish General Hospital, Montreal, QC H3T 1E2, Canada.
Nicoletta EliopoulosLady Davis Institute for Medical Research, SMBD-Jewish General Hospital, Montreal, QC H3T 1E2, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose-derived stromal/stem cells (ASCs) are promising for the treatment of many diseases, including tissue injury or degeneration associated with serious disease and high morbidity. The extent of cell therapy effectiveness, however, may be limited by the lower survival of implanted cells in environments of tissue damage. Therefore, strategies to improve cell survival are important, such as by pretreating/preconditioning cells with a beneficial agent. We investigated the pretreatment of human ASCs (hASCs) with StemRegenin 1 (SR1), a purine derivative used in clinical protocols for

Indexed as

adipose-derived stromal/stem cellsantimycin AASCscell therapymesenchymal stromal/stem cellsMSCspreconditioningSR1StemRegenin 1

Identifiers

PMID41257286
PMCPMC12621439

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.