ReviewAnnals of medicine2025
Chronic obstructive pulmonary disease (COPD) and autoimmune diseases: unravelling complex interactions.
Review in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Unfolding Immune Dysregulation in COPD: Identification of a Three-Gene Signature and Functional Validation ofInternational journal of molecular sciences · 2026Article
- Development of a Bedside Decision Tree for Postexacerbation Risk Stratification: Translating Neuroimmune Biomarker Dynamics Into Clinical Practice.Canadian respiratory journal · 2026Observational
- The gut-lung axis: pathological crosstalk and inter-organ communication in chronic obstructive pulmonary disease and inflammatory bowel disease.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic obstructive pulmonary disease (COPD) is a global healthcare problem, characterized by a progressive and irreversible decline in lung function, primarily due to airflow limitation caused by inflammation and emphysema. While smoking is the main risk factor, systemic inflammation also plays a significant role in the development and progression of the disease, particularly in relation to autoimmune conditions. RESEARCH QUESTION: This literature review provides an overview of current evidence regarding the underlying pathophysiological mechanisms that link autoimmune inflammatory processes to COPD. It also examines the clinical relevance of these associations, with a focus on potential diagnostic and therapeutic implications.
methodsTo ensure a comprehensive perspective, a broad literature search was conducted in PubMed and Embase in March 2025, using a wide range of search terms related to COPD and multiple autoimmune conditions. Relevant studies of any design were included if they provided valuable insights into the interplay between autoimmune processes and COPD, while non-English publications and commentaries were excluded.
resultsStudies suggest a potential association between COPD and autoimmune processes, with chronic systemic inflammation playing a central role. The evidence points to immune dysregulation as a contributing factor to both COPD progression and its connection to autoimmune conditions.
conclusionThe complex interactions between COPD and autoimmune diseases require further investigation. Gaining a better understanding of these interactions may provide new insights into managing patients with concurrent pulmonary and autoimmune conditions, emphasizing a growing area of clinical research.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.