Evidence map›Paper›PMID 41257710›Full record

ArticleBMC pregnancy and childbirth2025

Choice of laboratory insemination protocol for patients with emergency oocyte retrieval in natural cycles.

Qing Li, Min Zhang, Shuiying Ma, Xiuli Dong, Hui Liu, Dongsha Wang, Yang Song, Mei Li

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qing Li *The Second Qilu Hospital of Shandong University, Institute of Women, Children and Reproductive Health, Shandong University, No. 247, Beiyuan Street, Jinan, China.
Min Zhang *The Second Qilu Hospital of Shandong University, Institute of Women, Children and Reproductive Health, Shandong University, No. 247, Beiyuan Street, Jinan, China.
Shuiying MaState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.
Xiuli DongState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.
Hui LiuState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.
Dongsha WangThe Second Qilu Hospital of Shandong University, Institute of Women, Children and Reproductive Health, Shandong University, No. 247, Beiyuan Street, Jinan, China.
Yang SongThe Second Qilu Hospital of Shandong University, Institute of Women, Children and Reproductive Health, Shandong University, No. 247, Beiyuan Street, Jinan, China.
Mei LiState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China. lee_mei@163.com.

Funding

CAMS Innovation Fund for Medical Sciences 2021-I2M-5-001National Key Research and Development Program of China 2022YFC2703000National Natural Science Foundation of China 82171842National Special Support Program for High-level Talents, and Taishan Scholars Program for Young Experts of Shandong Province tsqn201909195Shandong Provincial Natural Science Foundation ZR2020QH046Shandong Provincial Natural Science Foundation ZR2022JQ33
6 · The paper itself

Abstract

objectiveTo determine the most effective insemination protocol for patients undergoing emergency oocyte retrieval in natural cycles, comparing immediate denudation and intracytoplasmic sperm injection (ICSI) versus overnight culture before ICSI.

designRetrospective study comparing two insemination protocols for patients undergoing emergency oocyte retrieval in natural cycles. SUBJECTS: Reproductive Medicine Department, Affiliated Reproductive Hospital of Shandong University, from 2015 to 2021.Women undergoing natural cycle IVF treatment with emergency oocyte retrieval due to declining estradiol (E2) levels. EXPOSURE (FOR OBSERVATIONAL STUDIES): Two groups were formed based on denudation and ICSI timing. Group E underwent immediate denudation on the day of oocyte retrieval, while Group L underwent overnight culture before ICSI.

main outcome measuresFertilization rate, high-quality embryo rate, oocyte utilization rate, and live birth rate from fresh and frozen embryo transfers.

resultsIn this study, no significant differences were found in overall embryonic development or clinical outcomes between Groups E and Group L. However, Group L exhibited a higher fertilization rate (87.87% vs. 77.12%, P = 0.002), and Group E achieved more higher-quality embryos (52.82% vs. 40.65%, P = 0.036). The oocyte utilization rates were comparable between groups (33.61% vs. 31.98%, P = 0.702). The overall live birth rate was also similar between groups (13.33% vs. 12.5%, P = 0.88).

conclusionsThese two protocols are feasible for patients in the natural cycle undergoing emergency oocyte retrieval. Group E achieved better results for fresh cycle transplantation. Group L showed a higher fertilization rate with reduced manipulation. To select protocols, clinicians should carefully consider patient-specific factors, including oocyte maturity and the clinical context.

Indexed as

Oocyte RetrievalSperm Injections, IntracytoplasmicAdultEmbryo TransferFemaleFertilization in VitroHumansPregnancyPregnancy RateRetrospective StudiesEmergency oocyte retrievalICSI timingIn-vitro maturationNatural-cycle IVF

Identifiers

PMID41257710
PMCPMC12628950

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.