Evidence map›Paper›PMID 41257944›Full record

ArticleClinical epigenetics2025

WTAP regulates NCOA4-mediated ferroptosis via a YTHDF2-dependent mechanism in preeclampsia.

Can Li, Zhiyuan Li, Chunling Ma, Lin Xu, Ning Zhang, Yan Li, Qingqing Lv, Chao Li, Shuping Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Can LiDepartment of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong Province, China.
Zhiyuan LiDepartment of Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong Province, China.
Chunling MaDepartment of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong Province, China.
Lin XuDepartment of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong Province, China.
Ning ZhangDepartment of Obstetrics and Gynecology, Qingdao Women and Children's Hospital, Qingdao, 266111, Shandong Province, China.
Yan LiDepartment of Obstetrics and Gynecology, Qingdao Women and Children's Hospital, Qingdao, 266111, Shandong Province, China.
Qingqing LvDepartment of Obstetrics and Gynecology, Qingdao Women and Children's Hospital, Qingdao, 266111, Shandong Province, China.
Chao LiDepartment of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong Province, China. lichaoqy@126.com.
Shuping ZhaoDepartment of Obstetrics and Gynecology, Qingdao Women and Children's Hospital, Qingdao, 266111, Shandong Province, China. zhaosp66@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreeclampsia (PE) is a pregnancy-specific hypertensive disorder associated with placental dysfunction and oxidative stress. This study explored whether WTAP regulates ferroptosis in trophoblasts through m

methodsWTAP expression and global m

resultsWTAP expression and global m

conclusionWTAP suppresses ferroptosis in PE by enhancing YTHDF2-dependent m

Indexed as

FerroptosisNuclear Receptor CoactivatorsPre-EclampsiaRNA-Binding ProteinsAnimalsCell ProliferationDisease Models, AnimalFemaleHumansMiceOxidative StressPeptide HormonesPlacentaPregnancyTrophoblastsAPELA protein, humanNCOA4 protein, humanNuclear Receptor CoactivatorsPeptide HormonesRNA-Binding ProteinsYTHDF2 protein, humanFerroptosisM6A methyladenosineNCOA4PreeclampsiaWTAP

Identifiers

PMID41257944
PMCPMC12628531

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.