Evidence map›Paper›PMID 41258072›Full record

ArticleExperimental & molecular medicine2025

SIRT3-IDH2 axis is a target of dietary fructose: implication of IDH2 as a key player in dietary carcinogen toxicity in mice colon.

Jeong Hoon Pan, Nukhet Aykin-Burns, Kimberly J Krager, Hyo Ri Shin, Chae Hwan Lee, Jin Hyup Lee, Byungwhi Kong, JaeEun Myoung, Kyung-Chul Choi, Jae Kyeom Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental & molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jeong Hoon PanDepartment of Health Behavior and Nutrition Sciences, University of Delaware, Newark, DE, USA.
Nukhet Aykin-BurnsDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas Medical Sciences, Little Rock, AR, USA.
Kimberly J KragerDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas Medical Sciences, Little Rock, AR, USA.
Hyo Ri ShinDepartment of Food and Biotechnology, Korea University, Sejong, Republic of Korea.
Chae Hwan LeeDepartment of Food and Biotechnology, Korea University, Sejong, Republic of Korea.
Jin Hyup LeeDepartment of Food and Biotechnology, Korea University, Sejong, Republic of Korea.
Byungwhi KongQuality and Safety Assessment Research Unit, US Department of Agriculture, Athens, GA, USA.
JaeEun MyoungDepartment of Biochemistry and Molecular Biology, Brain Korea 21 Project, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Kyung-Chul ChoiDepartment of Biochemistry and Molecular Biology, Brain Korea 21 Project, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. choikc75@amc.seoul.kr.ORCID http://orcid.org/0000-0001-9449-6163
Jae Kyeom KimDepartment of Health Behavior and Nutrition Sciences, University of Delaware, Newark, DE, USA. nutrigenomics@korea.ac.kr.ORCID http://orcid.org/0000-0002-2837-9302

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent epidemiological studies have shown that dietary fructose intake is associated with an increased risk of colorectal cancer, yet its specific molecular mechanisms in colon carcinogenesis remain underexplored. Here we investigate the molecular mechanisms by which dietary fructose contributes to colon carcinogenesis, focusing on the role of mitochondrial NADP

Indexed as

CarcinogensColonColonic NeoplasmsFructoseIsocitrate DehydrogenaseSirtuin 3AnimalsCarcinogenesisDietHumansMaleMiceMice, KnockoutSignal TransductionCarcinogensFructoseIsocitrate Dehydrogenaseisocitrate dehydrogenase 2, mouseSirt3 protein, mouseSirtuin 3

Identifiers

PMID41258072
PMCPMC12686511

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.