ArticleScientific reports2025
Exploring the role of hepatic lipid droplets in mouse liver toxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin: sequestration, biochemical alterations and gene regulation.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Lipid droplet biogenesis as a metabolic switch regulating ferroptosis sensitivity in cancer cells.The FEBS journal · 2026Review
- Quantitative Modeling of Lipid Droplet Contribution to Intracellular Drug Distribution and Efficacy of Tyrosine Kinase Inhibitors.ACS omega · 2026Article
- Subchronic low dose dioxin exposure disrupts hepatic and metabolic homeostasis in a sex- and diet-dependent manner.Current research in toxicology · 2026Article
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Authors and funding
3 authors.
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Abstract
Dioxins are highly toxic and persistent environmental pollutants. The liver, with its complex enzymatic system, plays a crucial role in their detoxification. Hepatic lipid droplets (LDs) are specialized organelles with diverse biological functions, yet their role in dioxin toxicity remains poorly understood. This study investigates the impact of TCDD, the most potent dioxin congener, on the biochemical properties and functionality of hepatic LDs in exposed mice. Female and male BALB/c mice (12-14 weeks old) received a single oral dose of 15-25 µg/kg bw, designated as TCDD
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