ArticleEMBO reports2025
NANOG governs cell metabolism and redox homeostasis in human naïve embryonic stem cells.
Article in EMBO reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Cell-Type-Specific Calibration of Mitochondrial Ubiquitination in Stem Cell Fate Decisions.Stem cell reviews and reports · 2026Review
- Article
- Endogenous VEGF signaling acts as a guardian of human primed pluripotency.Nature communications · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Naïve human embryonic stem cells (hESCs) possess some advantages over their primed counterparts, displaying distinctive metabolic and epigenetic properties. However, the master regulator governing these features remains unrecognized. Here, we systematically investigate functions of the core transcription factor NANOG in naïve hESCs. Acting as an upstream key regulator, NANOG directly activates genes associated with naïve pluripotency, acetyl-CoA synthesis and anti-oxidation in a naïve pluripotency state- dependent manner, and represses the expression of extraembryonic lineage genes in naïve hESCs. NANOG modulates transcription of multiple genes in various pathways of acetyl-CoA synthesis, maintains the intracellular acetyl-CoA level and characteristic epigenetic landscapes, particularly the high level of histone acetylation, in naïve hESCs. NANOG is indispensable for the high activity of both OXPHOS and glycolysis, a bivalent metabolic state typical in naïve hESCs. Furthermore, we identify GPX2 as a mediator of NANOG in sustaining redox balance and survival of naïve hESCs. Together, this study reveals previously unrecognized roles of NANOG in orchestrating transcriptional, metabolic and epigenetic signatures to secure human naïve pluripotency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.