Evidence map›Paper›PMID 41258178›Full record

ArticleScientific reports2025

The clinical implications of the interaction between hypothyroidism and diabetes mellitus.

Amar Babikir Elhussein, Ogail Yousif Dawod, Ibrahim Ismail Mohammed Abu, Walid G Babikr, Abdulrahman A Alsayegh, Abdullah Y Otayf, Mohammed F Bajahzer, Monami Mukherjee Mondal, Nusayba Abdelrhman Alageb, Mohamed M Almaki and 9 more

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Amar Babikir ElhusseinDepartment of Biochemistry, Faculty of Medicine, Nile College, P.O. Box 17001, Khartoum, Sudan.
Ogail Yousif DawodPhysical Therapy Department, College of Nursing and Health Sciences, Jazan University, P. O. Box 114, Jazan, 45142, Saudi Arabia. ogail76@gmail.com.
Ibrahim Ismail Mohammed AbuDepartment of Community Medicine, Faculty of Medicine, King Abdulaziz University, P. O. Box 9515, Jeddah, Saudi Arabia.
Walid G BabikrInternist-ECNHN, Postal Code 66262, Najran, Saudi Arabia.
Abdulrahman A AlsayeghDepartment of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, P. O. Box 114, Jazan, 45142, Saudi Arabia.
Abdullah Y OtayfDepartment of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, P. O. Box 114, Jazan, 45142, Saudi Arabia.
Mohammed F BajahzerDepartment of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, P. O. Box 114, Jazan, 45142, Saudi Arabia.
Monami Mukherjee MondalDepartment of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, P. O. Box 114, Jazan, 45142, Saudi Arabia.
Nusayba Abdelrhman AlagebDepartment of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, P. O. Box 114, Jazan, 45142, Saudi Arabia.
Mohamed M AlmakiDepartment of Medical Laboratory Sciences, Faculty of Nursing and Health Sciences, Jazan University, P. O. Box 114, Jazan, 45142, Saudi Arabia.
Badreldin S R AhmedDepartment of Medical Laboratory Sciences, Faculty of Nursing and Health Sciences, Jazan University, P. O. Box 114, Jazan, 45142, Saudi Arabia.
Ammar AbdelmolaDepartment of Medical Laboratory Sciences, Faculty of Nursing and Health Sciences, Jazan University, P. O. Box 114, Jazan, 45142, Saudi Arabia.
Saif Elden B AbdallaDepartment of Medical Laboratory Sciences, Faculty of Nursing and Health Sciences, Jazan University, P. O. Box 114, Jazan, 45142, Saudi Arabia.
Mohamed Eltaib ElmobarkClinical Pharmacy Department, College of Pharmacy, Jazan University, P. O. Box 114, Jazan, 45142, Saudi Arabia.
Nour Eldaim Elnoman ElbadawiDepartment of Biochemistry, College of Medicine, University of Shaqra, P. O. Box 473, Dawadmi, Saudi Arabia.
Husham E HomeidaDepartment of Maxillofacial Surgery and Diagnostic Science, College of Dentistry, Jazan University, P. O. Box 114, Jazan, 45142, Saudi Arabia.
Nahid Mahmoud Hassan ElaminDepartment of Maxillofacial Surgery and Diagnostic Science, College of Dentistry, Jazan University, P. O. Box 114, Jazan, 45142, Saudi Arabia.
Muntaser Mohammed Fadoul AlhassenDepartment of Diagnostic Radiology, College of Nursing and Health Sciences, Jazan University, P. O. Box 114, Jazan, 45142, Saudi Arabia.
Asaad KhalidSubstance Health Research Centre, Jazan University, P. O. Box 114, Jizan, 45142, Saudi Arabia.

Funding

Deanship of Graduate Studies and Scientific Research, Jazan University, Saudi Arabia Project Number: (JU- 202503171 -DGSSR- RP -2025)
6 · The paper itself

Abstract

This study aims to investigate the prevalence of hypothyroidism in T2DM patients and its relationship with lipid profiles and clinical parameters. The results indicate that 82% of the T2DM patients did not have hypothyroidism, whereas 18% had hypothyroidism. People with both conditions had a higher average body mass index (BMI) of 32.1 ± 6.1 kg/m² than those with only T2DM did (mean: 34.4 ± 6.8 kg/m², p < 0.001). Compared with the control group, the hypothyroid group presented higher glycosylated hemoglobin (HbA1c) levels (mean: 10.1% vs. 5.48%, p < 0.001). Compared with T2DM patients without hypothyroidism, T2DM patients with hypothyroidism presented significantly poorer lipid profiles, with lower high-density lipoprotein and higher low-density lipoprotein and triglyceride. T2DM patients with hypothyroidism had a greater prevalence of vitamin D deficiency (average: 28.2 ± 20.0 ng/mL) than control patients did (average: 59.5 ± 11.7 ng/mL, p < 0.001). In conclusion, T2DM with hypothyroidism is associated with poorer metabolic indicators than those of T2DM patients without hypothyroidism. Individuals who have both conditions have an increased BMI, higher FBS levels, poorer lipid profiles, and decreased vitamin D levels. These results highlight the importance of implementing specific management plans for T2DM patients who also have hypothyroidism.

Indexed as

Diabetes Mellitus, Type 2HypothyroidismAdultAgedBody Mass IndexCase-Control StudiesFemaleGlycated HemoglobinHumansLipidsMaleMiddle AgedPrevalenceTriglyceridesVitamin D DeficiencyGlycated HemoglobinLipidsTriglyceridesCardiovascular riskGlycemic controlHypothyroidismLipid profileType 2 diabetes mellitus (T2DM)

Identifiers

PMID41258178
PMCPMC12630881

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.