Evidence map›Paper›PMID 41258188›Full record

ReviewCurrent atherosclerosis reports2025

Exploring the Role of SPARC in Atherosclerosis: Mechanisms and Potential Implications.

Xiangyun Luo, Xingdan Luo, Si Tang, Yi Chen, Ruohan Xia, Xianwang Wang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current atherosclerosis reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiangyun LuoHealth Science Center, Yangtze University, Jingzhou, 434023, Hubei, China.
Xingdan LuoHealth Science Center, Yangtze University, Jingzhou, 434023, Hubei, China.
Si TangHealth Science Center, Yangtze University, Jingzhou, 434023, Hubei, China.
Yi ChenHealth Science Center, Yangtze University, Jingzhou, 434023, Hubei, China.
Ruohan XiaHealth Science Center, Yangtze University, Jingzhou, 434023, Hubei, China. rxia@yangtzeu.edu.cn.
Xianwang WangDepartment of Biochemistry and Molecular Biology, Center for Molecular Medicine, Health Science Center, Yangtze University, Jingzhou, 434023, Hubei, China. 500851@yangtzeu.edu.cn.

Funding

Key project of Natural Science Foundation of Tibet Autonomous Region XZ202501ZR0140Natural Science Foundation of Hubei Province 2025AFB925Shannan Science and Technology Plan Project SNSBJKJJHXM2024023
6 · The paper itself

Abstract

purpose of reviewAtherosclerosis, an inflammatory disease of large arteries, is a major cause of cardiovascular disease and stroke. Its pathogenesis involves complex interactions among endothelial cells, smooth muscle cells, macrophages, and other immune cells, forming atherosclerotic plaques. Secreted protein acidic and rich in cysteine (SPARC), a protein widely present in various cell types, participates in numerous biological processes. This review aims to explore the pathophysiologic role of SPARC in atherosclerosis and its significance in diagnosis and treatment. RECENT

findingsElevated expression of SPARC is observed in advanced atherosclerotic lesions and plasma concentrations of SPARC are higher in patients with ischemic cardiovascular disease. In a baboon model, SPARC expression correlates with LDL-C levels. However, the role and mechanism of SPARC in atherosclerosis remain to be explored. In this review, we elaborate on the critical roles of SPARC in endothelial dysfunction, macrophage polarization, smooth muscle cell proliferation, migration, and phenotypic transformation during the atherosclerotic process. The effects of SPARC on immune cells are also mentioned. Finally, we analyzed the potential of SPARC in the diagnosis and treatment of atherosclerosis.

Indexed as

AtherosclerosisOsteonectinAnimalsHumansMacrophagesOsteonectinSPARC protein, humanAtherosclerosisEndothelial cell dysfunctionMacrophage polarizationSPARCVascular smooth muscle cells

Identifiers

PMID41258188

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.