Evidence map›Paper›PMID 41258371›Full record

ArticleArchives of pharmacal research2025

Title: Resveratrol ameliorates liver fibrosis by inhibiting ATF4 to regulate glutamine metabolism in hepatic stellate cells.

Huiya Ying, Yixiao Wang, Dandan Zhu, Jun Xu, Xiangting Zhang, Hong Pan, Yuan Zeng, Xiao Wu, Weimin Cai, Ruoru Zhou and 2 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Archives of pharmacal research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Huiya YingDepartment of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Yixiao WangDepartment of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Dandan ZhuDepartment of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Jun XuDepartment of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xiangting ZhangDepartment of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Hong PanWenzhou Medical University, Wenzhou, China.
Yuan ZengDepartment of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xiao WuDepartment of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Weimin CaiDepartment of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Ruoru ZhouDepartment of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Ziqiang XiaDepartment of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Fujun YuDepartment of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. yufujun@wmu.edu.cn.ORCID http://orcid.org/0000-0001-5321-7228

Funding

Wenzhou Municipal Science and technology Bureau No. Y20220024Zhejiang Provincial Medical and Health Science and Technology Plan Project No. 2024KY1264Zhejiang Provincial Natural Science Foundation of China No. LY23H030003
6 · The paper itself

Abstract

Resveratrol has been shown to mitigate liver fibrosis by inhibiting the activation of hepatic stellate cells (HSCs). However, the precise mechanisms remain incompletely understood. Resveratrol demonstrates therapeutic potential in alleviating liver fibrosis by promoting HSC ferroptosis through the dual regulation of endoplasmic reticulum stress (ERS) and glutamine metabolism, as shown by in vivo and in vitro investigations. In carbon tetrachloride (CCl

Indexed as

Activating Transcription Factor 4GlutamineHepatic Stellate CellsLiver CirrhosisResveratrolAnimalsCarbon TetrachlorideDose-Response Relationship, DrugEndoplasmic Reticulum StressMaleMiceMice, Inbred C57BLActivating Transcription Factor 4Atf4 protein, mouseCarbon TetrachlorideGlutamineResveratrolEndoplasmic reticulum stressFerroptosisGlutamine metabolismHepatic stellate cellsResveratrol

Identifiers

PMID41258371

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.