Evidence map›Paper›PMID 41258496›Full record

ArticleCommunications medicine2025

Quantifying the impact of early life growth adversity on later life health.

Raphael Goldman-Pham, Matthew P Alter, Rebecca Bao, Sophie É Collins, Catherine L Debban, James P Allinson, Antony Ambler, Alain G Bertoni, Avshalom Caspi, Stephanie Lovinsky-Desir and 23 more

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In one paragraph

Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors.

Raphael Goldman-PhamDepartment of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0009-0007-1159-7702
Matthew P AlterDepartment of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
Rebecca BaoDepartment of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
Sophie É CollinsDepartment of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-6323-1127
Catherine L DebbanDepartment of Genome Sciences, University of Virginia, Charlottesville, VA, USA.
James P AllinsonFaculty of Medicine, Imperial College London National Heart and Lung Institute, London, UK.
Antony AmblerDepartment of Psychology, University of Otago - Ōtākou Whakaihu Waka, Dunedin, New Zealand.
Alain G BertoniDepartment of Public Health Sciences, Wake Forest University, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0002-7503-6273
Avshalom CaspiDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0003-0082-4600
Stephanie Lovinsky-DesirDepartment of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Magnus P EkstromDepartment of Clinical Sciences, Lund University, Lund, Sweden.
James C EngertDepartment of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-8411-4790
David R JacobsSchool of Public Health, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-7232-0543
Daniel MalinskyDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA.
Ani ManichaikulDepartment of Genome Sciences, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-5998-795X
Erin D MichosDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-5547-5084
Terrie E MoffittDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Elizabeth C OelsnerDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-7481-9671
Sandhya RamrakhaDepartment of Psychology, University of Otago - Ōtākou Whakaihu Waka, Dunedin, New Zealand.
Stephen S RichDepartment of Genome Sciences, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0003-3872-7793
Coralynn SackDepartment of Medicine and Department of Environmental & Occupational Health Sciences, School of Medicine, University of Washington, Seattle, WA, USA.
Sanja StanojevicDepartment of Community Health and Epidemiology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Padmaja SubbaraoDepartment of Paediatrics and Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.ORCID http://orcid.org/0000-0003-0394-1933
Karen SugdenDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Reremoana TheodoreDepartment of Psychology, University of Otago - Ōtākou Whakaihu Waka, Dunedin, New Zealand.
Karol E WatsonDepartment of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Benjamin WilliamsDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Bin YangDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA.
Josée DupuisDepartment of Epidemiology, Biostatistics and Occupational Health, School of Population and Global Health, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-2871-3603
Seif O ShaheenWolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
R Graham BarrDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Robert J HancoxDepartment of Preventive & Social Medicine, Dunedin School of Medicine, University of Otago - Ōtākou Whakaihu Waka, Dunedin, New Zealand.ORCID http://orcid.org/0000-0002-3922-7144
Benjamin M SmithDepartment of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada. benjamin.m.smith@mcgill.ca.ORCID http://orcid.org/0000-0002-0619-5799

Funding

Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2M
Task Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2M
Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
Is mental disorder a preventable cause of age-related disease? The Dunedin Study.R01AG032282 · NIA · DUKE UNIVERSITY · PI CASPI, AVSHALOM, MOFFITT, TERRIE E · 2009 to 2025
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Chronic obstructive pulmonary disease in non-smokersR01HL130506 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HERBSTMAN, JULIE BETH, SMITH, BENJAMIN M. · 2016 to 2025
$6.3M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) 193740NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHGRI NIH HHS U54 HG003067NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL130506NHLBI NIH HHS R01 HL155816NIA NIH HHS R01 AG032282NIEHS NIH HHS K23 ES030725U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01-HL077612U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01-HL130506Wellcome Trust
6 · The paper itself

Abstract

backgroundEarly-life growth adversity is important to later-life health, but precision assessment in adulthood is challenging. We evaluated whether the difference between attained and genotype-predicted adult height ("height-GaP") would associate with prospectively ascertained early-life growth adversity and later-life all-cause and cardiovascular mortality.

methodsData were first analyzed from the Avon Longitudinal Study of Parents and Children (ALSPAC; n = 4582; 56/43% female/male) and UKBiobank (n = 483,385; 54/46% female/male). Genotype-predicted height was calculated using a multi-ancestry polygenic height score. Height-GaP was calculated as the difference between measured and genotype-predicted adult height. Early-life growth conditions were ascertained prospectively via standardized procedures (ALSPAC) and mortality via death register (UKBiobank). Regression models examined: (i) adult height-GaP as the outcome with early-life growth conditions as predictors; and (ii) mortality as the outcome with adult height-GaP as predictor. All models were adjusted for age, sex, genotype-predicted height and genetic ancestry. Analyses were replicated in the Dunedin Multidisciplinary Health and Development Study (DMHDS; n = 855; 49/51% female/male) and the Multi-Ethnic Study of Atherosclerosis (MESA; n = 6352; 52/48% female/male).

resultsHere we show that among ALSPAC participants (median [IQR] age: 24 [18-25] years at height-GaP assessment), lower gestational age at birth, greater pre- and post-natal deprivation indices, tobacco smoke exposure and less breastfeeding are associated with larger adult height-GaP deficit (p < 0.01). Among UKBiobank participants (mean ± SD age: 56 ± 8 years at height-GaP assessment), height-GaP deficit is associated with death from all-causes (adjusted hazard ratio comparing highest-to-lowest height-GaP deficit quartile [aHR]: 1.25 95%CI: 1.21-1.29), atherosclerotic cardiovascular disease (aHR: 1.32 95%CI: 1.23-1.42) and coronary heart disease (aHR: 1.64 95%CI: 1.49-1.81). Early- and later-life height-GaP associations replicate in DMHDS and MESA.

conclusionsThis study introduces a precision index of early-life growth adversity deployable in adulthood to investigate the developmental origins of longevity and improve health equity across the life course.

Identifiers

PMID41258496
PMCPMC12749450

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.