ArticleScientific reports2025
circRNA-associated-ceRNA networks in patients with traumatic tracheal stenosis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Traumatic tracheal stenosis (TTS) is one of the most commonly seen iatrogenic airway injuries caused by tracheal intubation or tracheotomy, which can harm the lives of patients in severe cases. Circular RNA (circRNA) is related to a variety of human diseases. However, the role that circRNAs are likely to play in traumatic tracheal stenosis is not known to a large extent till now. This research is designed to identify potential biomarkers and learn more about the mechanism of TTS through the establishment of a circRNA-associated ceRNA network. By carrying out RNA sequencing (RNA-seq), the expression profiles of circRNAs and mRNAs were explored from four TTS patients and four normal control cases. To investigate the differentially expressed circRNAs and mRNAs, this research performed both Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses. A circRNA-miRNA-mRNA network was predicted and established using bioinformatics tools including Mireap, Miranda, TargetScan, the circBase database, and miRTarBase. And then verified by utilizing RT-qPCR assays from six TTS patients and six normal control cases. In clinical tissue samples of the TTS group and the control group, 603 circRNAs and 1950 mRNAs were differentially expressed. According to GO and KEGG analyses, the differentially expressed circRNAs mainly participated in lysine degradation, platelet activation, and the VEGF/HIF-1 signaling pathway, whereas the differentially expressed mRNAs mainly participated in cytokine-cytokine receptor interaction, ECM-receptor interaction, neutrophil extracellular trap formation, and the PI3K-Akt signaling pathway. By utilizing 17 circRNAs, 7 miRNAs, and 9 mRNAs, a competing endogenous RNA (ceRNA) network was set up. Using RT-qPCR assay, It was confirmed that S100A2 and circ_030284 were upregulated, while miR-1207-5p was downregulated in TTS patients compared to normal controls, consistent with the gene chip outcomes. The research presents a comprehensive circRNA-associated ceRNA network in patients with TTS, which provides novel insights into TTS’s underlying pathogenesis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.