ArticleCerebellum (London, England)2025
Biological Age Prediction of the Cerebellar Vermis in the Human Lifespan.
Article in Cerebellum (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
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Abstract
The cerebellar vermis undergoes diverse structural changes with aging, yet region-specific aging patterns remain underexplored. Using Brain Structure Age (BSA), a deep learning biomarker from structural magnetic resonance imaging (MRI), we aimed to: (1) evaluate effects of volume, BMI, and education on vermis aging; (2) examine sex differences; and (3) analyze aging trajectories across young (20-39), middle-aged (40-59), and older adults (≥ 60). A cross-sectional study of 245 healthy participants from the Iranian Brain Imaging Database utilized high-resolution 3D T1-weighted images from a 3T MRI with a 64-channel coil. We calculated BSA and cerebellar vermis subregional volumes (lobules I-V, VI-VII, VIII-X). ANCOVA models examined the impact of age group, sex, BMI, education, and vermis volume on biological age, with Bonferroni-adjusted post hoc comparisons. The results revealed robust age-dependent gradients, with posterior lobules VIII-X showing the steepest decline (adjusted R
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