Evidence map›Paper›PMID 41258623›Full record

ArticleMolecular biology reports2025

Association of vitamin D receptor gene polymorphisms ApaI (rs7975232) and BsmI (rs1544410) with hepatocellular carcinoma susceptibility in Egyptian patients.

Salma Saleh Alrdahe, Aishah E Albalawi, Doaa Bahaa Eldin Darwish, Awatif M E Omran, Nada Mohammed Almasaudi, Afaf M Elsaid, Magdy M Youssef

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Salma Saleh AlrdaheDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk, 71491, Saudi Arabia. salrdahe@ut.edu.sa.ORCID http://orcid.org/0000-0002-8243-6275
Aishah E AlbalawiDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk, 71491, Saudi Arabia.ORCID http://orcid.org/0000-0002-7695-8691
Doaa Bahaa Eldin DarwishDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk, 71491, Saudi Arabia.ORCID http://orcid.org/0000-0002-2646-3340
Awatif M E OmranDepartment of Biochemistry, Faculty of science, University of Tabuk, Tabuk, Saudi Arabia.ORCID http://orcid.org/0000-0001-7803-3273
Nada Mohammed AlmasaudiDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk, 71491, Saudi Arabia.
Afaf M ElsaidGenetic Unit, Children Hospital Mansoura University, Mansoura, Egypt.
Magdy M YoussefBiochemistry Division, Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt. mmm_youssef@mans.edu.eg.ORCID http://orcid.org/0000-0003-4205-5379

Funding

The Deanship of Scientific Research at University of Tabuk, Tabuk, Saudi Arabia S-1442-0184
6 · The paper itself

Abstract

backgroundGlobally, hepatocellular carcinoma (HCC) is a widespread cancer, with a rising incidence rate. Polymorphisms in the vitamin D receptor (VDR) gene were found to be related to the emergence of tumors in various organs.

aimThis study aimed to examine the association of the polymorphic VDR gene with HCC development in Egyptian patients.

methodsGene polymorphism analyses for VDR ApaI (rs7975232 A > C) and VDR BsmI (rs1544410 C > T) variants were performed for 100 patients with HCCs and 100 cancer-free controls, using the ARMS-PCR.

resultsRegarding ApaI (rs7975232 C > A) SNP, the percentage of variant C-allele was substantially higher in the HCC group than in the control (p < 0.001). Additionally, the ApaI (rs7975232) variant conferred a ~ 4-fold, 4-fold, and 5-fold risk for HCC, respectively, through the codominant (OR = 4.0), dominant (OR = 3.77), and allelic (OR = 5.44) models. Moreover, the dominant model of ApaI (rs7975232) showed a progressive disease state defined by the higher ascites grade, higher tumor grade, higher histopathological grade, larger tumor size, and more lymph node invasion compared to those carrying the wild-type genotype (p < 0.001, < 0.001, 0.002, 0.01, < 0.001 and 0.02, respectively). Conversely, the BsmI (rs1544410 C > T) SNP showed no significant association with the HCC incidence and outcome.

conclusionour study revealed that the ApaI (rs7975232 A > C) SNP conferred a considerable risk for HCC incidence and progression among Egyptian patients. The study is limited by the relatively small sample size and restriction to an Egyptian cohort; further studies in larger and ethnically diverse populations are required to confirm these findings.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsReceptors, CalcitriolAdultAllelesCase-Control StudiesEgyptFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotideReceptors, CalcitriolVDR protein, humanApa1Bsm1HCCPolymorphismVDR

Identifiers

PMID41258623

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.