ArticleDiscover oncology2025
Triglyceride glucose related indices predict incident breast cancer risk in a population based cohort study.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Insulin resistance as a modifiable contributor to breast cancer: mechanisms, biomarkers, and therapeutic implications.Discover oncology · 2026Review
- Correlation between TyG index and its modified index with breast cancer risk in women a study based on NHANES database and real-world data.Frontiers in oncology · 2026Article
- The correlation between the triglyceride-glucose index and the odds of cervical cancer.Frontiers in oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between triglyceride-glucose (TyG)-related indices and breast cancer risk is not fully understood. This study aimed to investigate the role of TyG-related indices in predicting breast cancer risk.
methodsWe analyzed data from 220,396 female participants in the UK Biobank, with a median follow-up of 13.63 years. TyG-related indices including TyG, TyG-body mass index (TyG-BMI), TyG-waist circumference (TyG-WC), TyG-waist to height ratio (TyG-WHtR), TyG-waist to hip ratio (TyG-WHR). Cox proportional hazards models were used to evaluate the association between TyG-related indices and breast cancer risk. Mediation analysis was performed to assess the role of white blood cell (WBC) and C-reactive protein (CRP) in this association. Interaction analysis was conducted to assess if age, menopausal status, and breast cancer screening modified the association between TyG-related indices and breast cancer risk.
resultsThe highest quartiles of TyG, TyG-BMI, TyG-WC, TyG-WHtR, and TyG-WHR were significantly associated with increased breast cancer risk, with hazard ratios (95% CI) of 1.10 (1.04-1.17), 1.28 (1.20-1.35), 1.30 (1.22-1.38), 1.23 (1.16-1.31), and 1.17 (1.10-1.24), respectively. Interaction analysis revealed stronger associations in postmenopausal women, those aged ≥ 60, and individuals who had not undergone breast cancer screening (P for interaction < 0.05). Mediation analysis showed that CRP contributed a larger proportion of the mediation effect than WBC, with CRP mediating 26.8%-54.7% and WBC mediating 14.3%-40.4%.
conclusionTyG-related indices were significantly associated with increased breast cancer risk, highlighting their potential as biomarkers for risk assessment and prevention strategies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.