Evidence map›Paper›PMID 41259103›Full record

ReviewEuropean heart journal2026

Cardiac endogenous transmitter system: molecular features, functions, and clinical implications.

Duanyang Xie, Dandan Liang, Liping Zhou, Yi Liu, Yi-Han Chen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European heart journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Duanyang XieDepartment of Cardiology and State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Dandan LiangDepartment of Cardiology and State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Liping ZhouDepartment of Cardiology and State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Yi LiuDepartment of Cardiology and State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Yi-Han ChenDepartment of Cardiology and State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0003-1000-1835

Funding

Key Research Center Construction Project of Shanghai 2022ZZ01008National Key Clinical SpecialtyNational Natural Science Foundation of China 82088101Shanghai Key Clinical Specialty Project shslczdzk06202Top-level Clinical Discipline Project of Shanghai Pudong District PWYgf2021-01
6 · The paper itself

Abstract

Transmitter systems are molecular networks that facilitate signal transmission between neurons or between neurons and effector cells. Well-established examples include the glutamatergic, cholinergic, GABAergic, dopaminergic, serotonergic, and histaminergic systems. Traditionally, the heart was thought to lack its own endogenous transmitter systems (ETSs). However, recent studies have identified several such systems within cardiomyocytes and cardiac pacemaker cells. This review focuses on the endogenous glutamatergic, cholinergic, and GABAergic systems in the heart, providing a comprehensive analysis of their molecular composition, electrophysiological functions, arrhythmogenic implications, and therapeutic potential. Based on these findings, this review proposes a transmitter-based model of cardiac bioelectric regulation and highlights innovative strategies for targeting ETSs to prevent and treat arrhythmias.

Indexed as

HeartNeurotransmitter AgentsAnimalsArrhythmias, CardiacGlutamic AcidHumansMyocytes, CardiacGlutamic AcidNeurotransmitter AgentsCardiac arrhythmiasCardiac electrophysiologyCholinergic systemGABAergic systemGlutamatergic systemTherapeutic targets

Identifiers

PMID41259103
PMCPMC12777706

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.