ArticleAmerican journal of physiology. Renal physiology2026
Macrophages and TGFB signaling regulate fibrosis in the
Abstract read
In one paragraph
Article in American journal of physiology. Renal physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Brandon R ScharpfDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Jaskiran SandhuDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Hannah RuettenDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0001-6263-6221
Hongtae ParkDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Robbie ManuelDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0003-3761-8712
Olivia FoxDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Anne E TurcoDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Shreya S NairDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Elliot HeyeDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0009-0004-9472-7696
Marcela AmbrogiDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0001-6030-1129
Sneha ChandrashekarDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Akhil PidikitiDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Allison RundquistDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Nicholas J SteersDivision of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, United States.
Lisa ArendtDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0002-7954-3635
Marulasiddappa SureshDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Douglas W StrandUniversity of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research, Madison, Wisconsin; Boston, Massachusetts; Dallas, Texas, United States.ORCID 0000-0002-0746-927X
Chad M VezinaDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0001-7058-5399
Funding
University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9MUT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MELANIE H. COBB · 2010 to 2026
$53.7MRole of Beta-Catenin in Urinary DysfunctionU54DK104310 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI MACOSKA, JILL A., MARKER, PAUL C · 2014 to 2023
$12.8MMolecular & Environmental Toxicology Pre-& Postdoctoral Training ProgramT32ES007015 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI CHRISTOPHER A BRADFIELD · 1985 to 2026
$11.5MNRSA Training CoreTL1TR002375 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI Vivek Prabhakaran · 2017 to 2026
$8.4MREPRODUCTIVE AND DEVELOPMENTAL TOXICITY OF DIOXINR01ES001332 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI PETERSON, RICHARD EUGENE, VEZINA, CHAD M. · 1985 to 2021
$5.3MBedside to bench resources for lower urinary tract researchRC2DK129994 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Douglas William Strand, CHAD M. VEZINA · 2022 to 2026
$5.0MLaboratory Animal & Comparative Medicine TrainingT32OD010957 · OD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI J. MARK CLINE · 2012 to 2026
$4.3MPQ2 Obesity-induced fibrocytes promote breast cancer progressionR01CA227542 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI ARENDT, LISA M · 2018 to 2022
$1.7MMolecular and fate maps of prostatic stromaU01DK110807 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI VEZINA, CHAD M. · 2016 to 2020
$1.6MInterstitial fibroblasts drive prostate branching morphogenesisR01DK135535 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Douglas William Strand · 2023 to 2026
$1.4MProstate inflammation increases collagen and voiding dysfunctionF30DK122686 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI RUETTEN, HANNAH MARGARET · 2019 to 2022
$157kHHS | NIH | National Cancer Institute (NCI) R01CA227542HHS | NIH | National Center for Advancing Translational Sciences (NCATS) TL1TR002375HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) F30DK122686HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK135535HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) RC2DK129994HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) U01DK110807HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) U54DK104310HHS | NIH | National Institute of Environmental Health Sciences (DEHS) R01ES001332NCATS NIH HHS TL1 TR002375NCATS NIH HHS UL1 TR002373NCI NIH HHS P30 CA142543NCI NIH HHS R01 CA227542NIDDK NIH HHS F30 DK122686NIDDK NIH HHS R01 DK135535NIDDK NIH HHS RC2 DK129994NIDDK NIH HHS U01 DK110807NIDDK NIH HHS U54 DK104310NIEHS NIH HHS R01 ES001332NIEHS NIH HHS T32 ES007015NIH HHS T32 OD010957
Abstract
Prostate inflammation and fibrosis are linked to lower urinary tract symptoms (LUTS) in men. Uropathogenic
Indexed as
Escherichia coli InfectionsMacrophagesProstateProstatitisTransforming Growth Factor beta1Uropathogenic Escherichia coliAnimalsAntigens, LyCollagenDisease Models, AnimalFibrosisMacrophage Colony-Stimulating FactorMaleMiceMice, Inbred C57BLMonocytesAntigens, LyCcr2 protein, mouseCollagenLy-6C antigen, mouseMacrophage Colony-Stimulating FactorReceptors, CCR2Tgfb1 protein, mouseTransforming Growth Factor beta1collagenfibrocytelower urinary tract symptomsmacrophageprostate
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.