Evidence map›Paper›PMID 41259141›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

A periplasmic zinc capture protein enhances the resistance of

Ian K Liyayi, Aloke Kumar Bera, Yasiru R Perera, Nourin Ferdausi, Indu Bhatia, Nicholas Noinaj, Walter J Chazin, Cynthia Nau Cornelissen, Alison K Criss

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. A periplasmic zinc capture protein enhances the resistance ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ian K LiyayiDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA 22908.ORCID 0000-0002-1713-123X
Aloke Kumar BeraDepartment of Biological Sciences, Purdue University, West Lafayette, IN 47907.
Yasiru R PereraCenter for Structural Biology, Vanderbilt University, Nashville, TN 37240.
Nourin FerdausiDepartment of Biological Sciences, Purdue University, West Lafayette, IN 47907.ORCID 0000-0002-0839-5583
Indu BhatiaCenter for Structural Biology, Vanderbilt University, Nashville, TN 37240.ORCID 0000-0001-7111-2622
Nicholas NoinajDepartment of Biological Sciences, Purdue University, West Lafayette, IN 47907.ORCID 0000-0001-6361-2336
Walter J ChazinCenter for Structural Biology, Vanderbilt University, Nashville, TN 37240.ORCID 0000-0002-2180-0790
Cynthia Nau CornelissenInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303.
Alison K CrissDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA 22908.ORCID 0000-0001-7738-3757

Funding

User Training & OutreachP30GM138396 · NIGMS · UCHICAGO ARGONNE, LLC · PI JANET L. SMITH · 2020 to 2026
$34.3M
The Biophysics Collaborative Access Team (User Training and Outreach)P30GM138395 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI THOMAS C IRVING · 2021 to 2026
$16.5M
INFECTIOUS DISEASES TRAINING PROGRAMT32AI007046 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Alison K Criss, William A Petri · 1985 to 2026
$15.3M
Neisseria gonorrhoeae metal transporters that subvert nutritional immunityR01AI127793 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI CYNTHIA N CORNELISSEN, Alison K Criss · 2017 to 2026
$6.8M
Survival of Neisseria gonorrhoeae after primary human neutrophil challengeR01AI097312 · NIAID · UNIVERSITY OF VIRGINIA · PI CRISS, ALISON K · 2012 to 2022
$4.6M
High-Speed High-Sensitivity Detector for X-ray Micro-Crystallography at GM/CA@APSS10OD012289 · OD · UNIVERSITY OF CHICAGO · PI FISCHETTI, ROBERT F. · 2014 to 2014
$2.0M
Survival of Neisseria gonorrhoeae after primary human neutrophil challengeR37AI097312 · NIAID · UNIVERSITY OF VIRGINIA · PI Alison K Criss · 2025 to 2026
$1.1M
Advanced Pixel Array Detector for Time-Resolved SAXS and Fiber DiffractionS10OD018090 · OD · ILLINOIS INSTITUTE OF TECHNOLOGY · PI IRVING, THOMAS C · 2014 to 2014
$529k
Neisseria gonorrhoeae central metabolism in the context of neutrophilic inflammationR21AI161302 · NIAID · UNIVERSITY OF VIRGINIA · PI CRISS, ALISON K · 2021 to 2022
$444k
Understanding the role of Ngo1049 in subverting host-mediated metal starvation in Neisseria gonorrhoeaeF31AI167563 · NIAID · UNIVERSITY OF VIRGINIA · PI LIYAYI, IAN KIMANI · 2022 to 2024
$143k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) F31AI167563HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI097312HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI127793HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R21AI161302HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) T32AI007046NIAID NIH HHS F31 AI167563NIAID NIH HHS R01 AI097312NIAID NIH HHS R01 AI127793NIAID NIH HHS R21 AI161302NIAID NIH HHS R37 AI097312NIAID NIH HHS T32 AI007046NIGMS NIH HHS P30 GM138395NIGMS NIH HHS P30 GM138396NIH HHS S10 OD012289NIH HHS S10 OD018090
6 · The paper itself

Abstract

During microbial infection, mammalian hosts reduce the availability of free metals such as zinc in a process known as nutritional immunity. Pathogens counteract nutritional immunity by expressing gene products that enhance growth in metal-limited conditions. One of the most transcriptionally induced genes in zinc-limited

Indexed as

Bacterial ProteinsNeisseria gonorrhoeaePeriplasmZincGonorrheaHumansBacterial ProteinsZincmetalNeisseria gonorrhoeaenutritional immunityperiplasmzinc

Identifiers

PMID41259141
PMCPMC12663993

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.