Evidence map›Paper›PMID 41259153›Full record

ArticleMolecular biology of the cell2026

Hubert Osei Acheampong, Emily Rozich, Zachary Haupt, Charlee Tokarz, Mousumee Khan, Zahraa A Ghosn, Ryan Insolera

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hubert Osei AcheampongOphthalmology, Visual, and Anatomical Sciences Department, Wayne State University School of Medicine, Detroit, MI 48201.
Emily RozichOphthalmology, Visual, and Anatomical Sciences Department, Wayne State University School of Medicine, Detroit, MI 48201.
Zachary HauptOphthalmology, Visual, and Anatomical Sciences Department, Wayne State University School of Medicine, Detroit, MI 48201.
Charlee TokarzOphthalmology, Visual, and Anatomical Sciences Department, Wayne State University School of Medicine, Detroit, MI 48201.
Mousumee KhanOphthalmology, Visual, and Anatomical Sciences Department, Wayne State University School of Medicine, Detroit, MI 48201.
Zahraa A GhosnOphthalmology, Visual, and Anatomical Sciences Department, Wayne State University School of Medicine, Detroit, MI 48201.
Ryan InsoleraOphthalmology, Visual, and Anatomical Sciences Department, Wayne State University School of Medicine, Detroit, MI 48201.ORCID 0000-0001-8282-9370

Funding

Mechanisms of mitophagy in tissue health and homeostasisR35GM156765 · NIGMS · WAYNE STATE UNIVERSITY · PI Ryan Insolera · 2025 to 2026
$746k
Mechanistic investigation of in vivo pathways of neuronal mitochondrial degradationR00NS111000 · NINDS · WAYNE STATE UNIVERSITY · PI INSOLERA, RYAN · 2022 to 2024
$735k
NIGMS NIH HHS R35 GM156765NINDS NIH HHS R00 NS111000
6 · The paper itself

Abstract

The maintenance of healthy mitochondria is essential to neuronal homeostasis. Mitophagy is a critical mechanism that degrades damaged mitochondria, and disruption of this process is associated with neurodegenerative disease. Previous work has shown that mammalian optineurin (OPTN), a gene mutated in familial forms of amyotrophic lateral sclerosis (ALS) and glaucoma, is an adaptor to recruit autophagy machinery to mitochondria for ubiquitin-dependent mitophagy in cultured cells. However, OPTN's role in neuronal mitophagy

Indexed as

Drosophila ProteinsMitophagyUbiquitinAnimalsAutophagyDrosophila melanogasterMitochondriaMotor NeuronsNeuronsTranscription Factor TFIIIAUbiquitinationValosin Containing ProteinDrosophila Proteinster94 protein, DrosophilaTranscription Factor TFIIIAUbiquitinValosin Containing Protein

Identifiers

PMID41259153
PMCPMC12879043

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.