Evidence map›Paper›PMID 41259212›Full record

SynthesisJournal of diabetes investigation2026

Association between stress hyperglycemia ratio and prognosis of patients hospitalized with COVID-19: A meta-analysis.

Lizhan Chen, Mingming Wang, Jie Chen

Abstract readMeta-Analysis
In one paragraph

Synthesis in Journal of diabetes investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lizhan ChenDepartment of Respiratory and Critical Care Medicine, Xi'an International Medical Center Hospital, Xi'an, China.
Mingming WangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Air Force Medical University, Xi'an, China.
Jie ChenDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Air Force Medical University, Xi'an, China.ORCID https://orcid.org/0009-0003-6247-6258

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AIMS/

introductionStress hyperglycemia ratio (SHR), calculated by dividing admission glucose levels by estimated chronic glucose levels, has emerged as a novel marker of glycemic stress. However, its prognostic value in patients hospitalized with COVID-19 remains unclear. This meta-analysis investigates the association between SHR and adverse outcomes in this population. MATERIALS AND

methodsA comprehensive literature search was conducted in PubMed, Embase, and Web of Science databases for relevant observational studies. The primary outcome was a composite of ICU admission, invasive mechanical ventilation (IMV), and all-cause in-hospital mortality. Secondary outcomes included the individual components of the primary outcome. A random effects model was used to pool the results by incorporating heterogeneity.

resultsSeven studies involving 2,272 patients were included. Patients with a high SHR had a significantly higher risk of poor composite outcomes (risk ratio [RR]: 1.93, 95% confidence interval [CI]: 1.54-2.43; I

conclusionsHigh SHR at admission is independently associated with poor prognosis in patients hospitalized with COVID-19. However, as admission glucose levels in most studies were not standardized for fasting status, SHR may be influenced by postprandial hyperglycemia, which should be considered when interpreting its prognostic value.

Indexed as

Blood GlucoseCOVID-19HyperglycemiaStress, PhysiologicalBiomarkersHospitalizationHospital MortalityHumansIntensive Care UnitsPrognosisRespiration, ArtificialSARS-CoV-2BiomarkersBlood GlucoseCOVID‐19PrognosisStress hyperglycemia ratio

Identifiers

PMID41259212
PMCPMC12757679

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.