Evidence map›Paper›PMID 41259217›Full record

ArticleBrazilian journal of cardiovascular surgery2026

The Relationship Between Aortic Tissue Sirtuin 1 Levels and Type A Aortic Dissections and Ascending Aortic Aneurysms.

Mehmet Rum, Bulend Ketenci, Fatih Kizilyel, Bahar Sarikamis Johnson, Ulkan Celik, Berfin Ekin Gozukara Yildiz, Abdulkerim Ozhan

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In one paragraph

Article in Brazilian journal of cardiovascular surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mehmet RumUniversity of Health Sciences Dr. Siyami Ersek Thoracic Cardiac and Vascular Surgery Hospital Department of Cardiovascular Surgery Istanbul Turkiye Department of Cardiovascular Surgery, Dr. Siyami Ersek Thoracic Cardiac and Vascular Surgery Hospital, University of Health Sciences, Istanbul, Turkiye.
Bulend KetenciUniversity of Health Sciences Dr. Siyami Ersek Thoracic Cardiac and Vascular Surgery Hospital Department of Cardiovascular Surgery Istanbul Turkiye Department of Cardiovascular Surgery, Dr. Siyami Ersek Thoracic Cardiac and Vascular Surgery Hospital, University of Health Sciences, Istanbul, Turkiye.
Fatih KizilyelUniversity of Health Sciences Dr. Siyami Ersek Thoracic Cardiac and Vascular Surgery Hospital Department of Cardiovascular Surgery Istanbul Turkiye Department of Cardiovascular Surgery, Dr. Siyami Ersek Thoracic Cardiac and Vascular Surgery Hospital, University of Health Sciences, Istanbul, Turkiye.
Bahar Sarikamis JohnsonUniversity of Health Sciences Hamidiye Institute of Health Sciences Department of Medical Biology Istanbul Turkiye Department of Medical Biology, Hamidiye Institute of Health Sciences, University of Health Sciences, Istanbul, Turkiye.
Ulkan CelikUniversity of Health Sciences Hamidiye Faculty of Medicine Department of Medical Biology Istanbul Turkiye Department of Medical Biology, Hamidiye Faculty of Medicine, University of Health Sciences, Istanbul, Turkiye.
Berfin Ekin Gozukara YildizUniversity of Health Sciences Haydarpasa Numune Education and Training Hospital Department of Pathology Istanbul Turkiye Department of Pathology, Haydarpasa Numune Education and Training Hospital, University of Health Sciences, Istanbul, Turkiye.
Abdulkerim OzhanKutahya Health Sciences University Kutahya City Hospital Department of Cardiovascular Surgery Kutahya Turkiye Department of Cardiovascular Surgery, Kutahya City Hospital, Kutahya Health Sciences University, Kutahya, Turkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionType A aortic dissections are pathologies with high mortality rates. Although ascending aortic aneurysms are typically planned for elective surgery, they are significant conditions in cardiovascular surgery due to their potential to cause type A aortic dissection. This study, which is the first to examine sirtuin 1 (SIRT1) in human ascending aortic tissues, aims to elucidate the relationship between ascending aortic pathologies and the SIRT1 protein.

methodsA case-control study was conducted using aortic tissues and demographic data from patients who underwent surgery for ascending aortic aneurysm and type A aortic dissection. Coronary artery bypass patients were selected as the control group. The groups were compared in terms of SIRT1 levels.

resultsThe study included a total of 46 patients (16 in the aneurysm group, 14 in the dissection group, and 16 in the control group). The SIRT1 protein level was the highest in the ascending aortic aneurysm group (214, interquartile range [IQR] 79 - 270), followed by the dissection group (172, IQR 148 - 224), and the lowest in the control group (104, IQR 78 - 123) (P = 0.014). SIRT1 level was found to be low in patients with coronary artery disease (P = 0.001), peripheral artery disease (P = 0.008), and hypertension (P = 0.023).

conclusionsType A aortic dissections are associated with elevated SIRT1 levels in the tissue. Systemic atherosclerotic diseases, such as coronary and peripheral artery diseases, are associated with decreased SIRT1 levels. There is also a relationship between hypertension and sirtuin1 levels.

Indexed as

AortaAortic AneurysmAortic DissectionSirtuin 1AgedAneurysm, Ascending AortaCase-Control StudiesFemaleHumansMaleMiddle AgedRisk FactorsSIRT1 protein, humanSirtuin 1Aortic AneurysmAortic DissectionsAscending Aorta AneurysmSirtuin 1.

Identifiers

PMID41259217
PMCPMC12661968

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.