Evidence map›Paper›PMID 41259454›Full record

ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2025

Biochanin A exerts an anti-inflammatory effect on adipose tissue and liver of ovariectomized obese mice.

J M D A Aragão, L Heimfarth, W S Neres, F B Felix, P R Dos Santos, F F Abreu, L M Cercato, A C S Nascimento, A B S Vasconcelos, R C Soares and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

J M D A AragãoPrograma de Pós-Graduação em Ciências Fisiológicas, Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.ORCID http://orcid.org/0000-0002-3381-6386
L HeimfarthDepartamento de Biofísica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.ORCID http://orcid.org/0000-0002-4503-8905
W S NeresPrograma de Pós-Graduação em Ciências Fisiológicas, Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.ORCID http://orcid.org/0000-0001-9617-4619
F B FelixDepartamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.ORCID http://orcid.org/0000-0002-2372-2781
P R Dos SantosDepartamento de Medicina, Universidade Federal de Rondônia, Porto Velho, RO, Brasil.ORCID http://orcid.org/0009-0007-7098-1886
F F AbreuPrograma de Pós-Graduação em Ciências Fisiológicas, Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.ORCID http://orcid.org/0000-0001-8395-2776
L M CercatoPrograma de Pós-Graduação em Ciências da Saúde, Departamento de Medicina, Hospital Universitário, Universidade Federal de Sergipe, Aracajú, SE, Brasil.ORCID http://orcid.org/0000-0003-2852-7309
A C S NascimentoPrograma de Pós-Graduação em Ciências Fisiológicas, Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.ORCID http://orcid.org/0009-0003-0268-5314
A B S VasconcelosDepartamento de Educação em Saúde, Universidade Federal de Sergipe, Lagarto, SE, Brasil.ORCID http://orcid.org/0000-0002-7481-2015
R C SoaresDepartamento de Morfologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.ORCID http://orcid.org/0000-0002-8392-9653
R L C de Albuquerque JúniorPrograma de Pós-Graduação em Odontologia, Centro de Ciências da Saúde, Departamento de Patologia, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.ORCID http://orcid.org/0000-0003-4444-7632
G I HeidenPrograma de Pós-Graduação em Odontologia, Centro de Ciências da Saúde, Departamento de Patologia, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.ORCID http://orcid.org/0009-0006-4193-8363
T R de MouraDepartamento de Morfologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.ORCID http://orcid.org/0000-0003-2436-6501
E A CamargoPrograma de Pós-Graduação em Ciências Fisiológicas, Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.ORCID http://orcid.org/0000-0003-2745-0768
R GrespanPrograma de Pós-Graduação em Ciências Fisiológicas, Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.ORCID http://orcid.org/0000-0003-3644-7632

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biochanin A (BCA), a phytoestrogen with broad therapeutic potential, is a promising molecule for alleviating post-menopausal symptoms and treating disorders related to reproductive metabolism. Nevertheless, the effect of BCA on inflammatory changes caused by postmenopausal obesity is unclear. Thus, this study focused on investigating the impact of BCA on the adipose tissue and liver of ovariectomized (OVX) mice subjected to a high-fat diet (HFD). We found that BCA treatment reduced the crown-like structures (CLS), adipocyte area, and hypertrophic adipocyte distribution. This was accompanied by an increase in the anti-inflammatory cytokines interleukin (IL)-5 and IL-10 and the expression of Mrc1 (CD206), a marker for M2 macrophages. Furthermore, there was a reduction in the extent of hepatic steatosis, triglyceride content, and the expression of Nos2, the M1 marker. We concluded that BCA exerted an anti-inflammatory response in the tissues, promoting a resolving profile, although the metabolic profile of the animals was not altered. This study was the first to demonstrate the anti-inflammatory effect of BCA in ovariectomized animals with established obesity.

Indexed as

Adipose TissueAnti-Inflammatory AgentsGenisteinLiverObesityAdipocytesAnimalsCytokinesDiet, High-FatDisease Models, AnimalFemaleMiceMice, Inbred C57BLMice, ObeseOvariectomyAnti-Inflammatory Agentsbiochanin ACytokinesGenistein

Identifiers

PMID41259454
PMCPMC12622944

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.