Evidence map›Paper›PMID 41260520›Full record

ReviewCurrent opinion in insect science2026

Genetic control of malaria transmission: a salivary gland-centric perspective.

Sabina Eze, Valerie T Nguyen, Alec Morvay, Yoosook Lee, Bianca Correa Burini

Abstract readReview
In one paragraph

Review in Current opinion in insect science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sabina EzeFlorida Medical Entomology Laboratory, IFAS, University of Florida, Vero Beach, FL 32962, USA.
Valerie T NguyenFlorida Medical Entomology Laboratory, IFAS, University of Florida, Vero Beach, FL 32962, USA.
Alec MorvayFlorida Medical Entomology Laboratory, IFAS, University of Florida, Vero Beach, FL 32962, USA.
Yoosook LeeFlorida Medical Entomology Laboratory, IFAS, University of Florida, Vero Beach, FL 32962, USA.
Bianca Correa BuriniFlorida Medical Entomology Laboratory, IFAS, University of Florida, Vero Beach, FL 32962, USA. Electronic address: bianca.kojin@ufl.edu.

Funding

Development of high-quality reference genomes for Anopheles squamosus and An. cydippisR03AI178041 · NIAID · UNIVERSITY OF FLORIDA · PI LEE, YOOSOOK · 2023 to 2024
$125k
NIAID NIH HHS R03 AI178041
6 · The paper itself

Abstract

Mosquitoes are the deadliest organisms on Earth, as they transmit a wide range of medically important diseases, posing a major public health threat worldwide. Controlling vector-borne diseases presents numerous challenges, and the alarming rise in their incidence underscores the urgent need for innovative strategies, with genetic control offering a promising approach. Genetic engineering of mosquitoes requires a profound understanding of mosquito physiology and molecular aspects of host-pathogen interactions. Over the years, several stages of the Plasmodium parasite development within the mosquito have been extensively studied, with many molecular mechanisms successfully elucidated. However, important features of the parasite journey remain unclear, particularly the sporozoite's ability to recognize and invade the salivary glands. This process involves a complex interplay of proteins and other molecules, yet much remains to be discovered about the precise mechanisms at play. Advancing our knowledge of this critical step will be instrumental in designing more effective transgenes for genetic control strategies, particularly those aimed at mosquito population replacement.

Indexed as

CulicidaeMalariaMosquito ControlMosquito VectorsPlasmodiumAnimalsHost-Parasite InteractionsSalivary Glands

Identifiers

PMID41260520
PMCPMC13288292

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.