Evidence map›Paper›PMID 41260604›Full record

ArticleJournal of microbiology and biotechnology2025

Plant-Derived Carotenoid Lutein Demonstrates Multifunctional Antiviral Activity against Influenza A Virus

Ju Won Kim, Han-Sol Ryu, Sanghyun Lee, Sejin Jeon, Sun-Woo Yoon, Yo Han Jang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of microbiology and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ju Won KimVaccine Biotechnology Major, Gyeongkuk National University, Andong 36729, Republic of Korea.
Han-Sol RyuVaccine Biotechnology Major, Gyeongkuk National University, Andong 36729, Republic of Korea.
Sanghyun LeeDepartment of Plant Science and Technology, Chung-Ang University, Anseong 17546, Republic of Korea.
Sejin JeonVaccine Biotechnology Major, Gyeongkuk National University, Andong 36729, Republic of Korea.
Sun-Woo YoonVaccine Biotechnology Major, Gyeongkuk National University, Andong 36729, Republic of Korea.
Yo Han JangVaccine Biotechnology Major, Gyeongkuk National University, Andong 36729, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza virus infections remain a major global health concern, causing annual outbreaks with high morbidity and mortality. The emergence of drug resistance and adverse effects from existing antivirals underscores the need for new therapeutic agents. This study presents the first evaluation of the antiviral activity and mechanisms of the dietary carotenoid lutein against influenza viruses. Lutein exhibited strong virucidal activity against influenza A (IAV) and B (IBV) viruses, as well as Japanese encephalitis virus (JEV), but showed only weak effects against the non-enveloped rotavirus, suggesting a preference for enveloped viruses. Dynamic light scattering analysis revealed that lutein disrupted viral particle integrity, causing aggregation and a reduction in particle numbers. Functional assays further demonstrated that lutein inhibited the activities of viral hemagglutinin (HA) and neuraminidase (NA). Lutein also suppressed viral replication when applied to cells both before and after infection, indicating its prophylactic and therapeutic potential. Collectively, these findings demonstrate that lutein exerts multifunctional antiviral effects through virucidal activity, inhibition of HA and NA activity, and suppression of viral replication. As the first report to elucidate lutein's multifaceted antiviral mechanisms, this study supports its potential as a natural antiviral candidate.

Indexed as

Antiviral AgentsInfluenza A virusLuteinAnimalsCell LineDogsEncephalitis Virus, JapaneseHemagglutinin Glycoproteins, Influenza VirusHumansInfluenza B virusMadin Darby Canine Kidney CellsNeuraminidaseRotavirusVirus ReplicationAntiviral AgentsHemagglutinin Glycoproteins, Influenza VirusLuteinNeuraminidaseantiviral agenthemagglutinininfluenza virusLuteinneuraminidasevirucidal activity

Identifiers

PMID41260604
PMCPMC12640769

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.