ArticleJournal for immunotherapy of cancer2025
Protein catenation potentiates antitumor activity of malaria VAR2CSA navigation CAR-T cells in a mouse model of hematological malignancies.
Article in Journal for immunotherapy of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The theory of tumor immuno-ecodynamics.Frontiers in immunology · 2026Article
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Authors and funding
13 authors.
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Abstract
backgroundWhile CD19-targeting chimeric antigen receptor T-cell (CAR-T) therapies have shown efficacy in B-cell hematological malignancies, treatment of antigen-negative or relapsed tumors remains challenging. The recombinant malaria protein VAR2CSA (rVAR2) binds specifically to placental-like chondroitin sulfate A (
methodsWe overexpressed and purified rVAR2 and three catenation proteins in
resultsWe developed an orthogonal CAR-T cell system that employs a navigator protein (rVAR2 or AXVB) to target
conclusionsProtein catenation improved the thermostability and functional activity of rVAR2. In a murine model of hematologic malignancy, CAR-T cells utilizing the rVAR2 catenane (AXVB) as a targeting module exhibited superior antitumor activity.
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