Evidence map›Paper›PMID 41261203›Full record

ArticleMolecular neurobiology2025

Modulating NLRP3 Inflammasome Activity and Enhancing Cortical Synaptic Plasticity: Nanoparticulate Hydrogen's Role in Relief of Post-traumatic Anxiety-like Behaviors in Rats.

Lanxia Wu, Congwen Yang, Yiqin Ding, Xinru Liu, Hao Sun, Xue Li, Yining Lu, Lifen Liu, Qingyang Fu, Min Li and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lanxia Wu *School of Psychology, Shandong Second Medical University, 7166# Baotong West Street, Weifang, Shandong, 261053, P. R. China.
Congwen Yang *The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China.
Yiqin DingSchool of Clinical Medicine, Shandong Second Medical University, 7166# Baotong West Street, Weifang, Shandong, 261053, China.
Xinru LiuSchool of Clinical Medicine, Shandong Second Medical University, 7166# Baotong West Street, Weifang, Shandong, 261053, China.
Hao SunSchool of Clinical Medicine, Shandong Second Medical University, 7166# Baotong West Street, Weifang, Shandong, 261053, China.
Xue LiSchool of Clinical Medicine, Shandong Second Medical University, 7166# Baotong West Street, Weifang, Shandong, 261053, China.
Yining LuSchool of Clinical Medicine, Shandong Second Medical University, 7166# Baotong West Street, Weifang, Shandong, 261053, China.
Lifen LiuFaculty of Psychology, Southwest University, Chongqing, 400715, China.
Qingyang FuDepartment of Orthopedics, Qilu Hospital of Shandong University, 107# Wenhua Xi Road, Jinan, Shandong, 250012, China.
Min LiWeifang University, Teacher Education College, Weifang, Shandong, 261061, China.
Yingshuai WangDepartment of Bioscience and Technology, Shandong Second Medical University, Weifang, Shandong, 261053, China.
Yuehan ZhaoDepartment of Clinical Psychology, Shandong Second Medical University, Weifang People's Hospital, Weifang, 261044, China.
Wenhao HanSchool of Psychology, Shandong Second Medical University, 7166# Baotong West Street, Weifang, Shandong, 261053, P. R. China.
Guohua LuSchool of Psychology, Shandong Second Medical University, 7166# Baotong West Street, Weifang, Shandong, 261053, P. R. China. luguohua@sdsmu.edu.cn.
Lin SunSchool of Psychology, Shandong Second Medical University, 7166# Baotong West Street, Weifang, Shandong, 261053, P. R. China. linsun2013@sdsmu.edu.cn.

Funding

Graduate Student Research Grant from Shandong Second Medical University 2023YJSCX009Graduate Student Research Grant from Shandong Second Medical University 2024YJSCX023Medical and Health Science and Technology Development Project of Shandong Province 202423010194National Natural Science Foundation of China 82101588
6 · The paper itself

Abstract

Post-traumatic stress disorder (PTSD) is a complex psychiatric disorder closely related to stress and traumatic events. Neuroinflammation and synaptic plasticity may play a role in the neurophysiological mechanisms of anxiety-like behaviors in PTSD. In this study, a novel magnesium hydrosilicide nanosheet (MSN) with anti-inflammatory and antioxidant properties was developed as a potential intervention for behavioral disorders associated with PTSD. Sustained hydrogen release was achieved through an optimized dosing regimen in a rat model subjected to single prolonged stress and electric foot shock (SPS&S), a validated paradigm for PTSD induction. Experimental results showed that a 7-day MSN intervention significantly attenuated anxiety-like behaviors while reversing the synaptic deficits induced by SPS&S in prefrontal cortical regions. Molecular analyses showed a concomitant downregulation of NOD-like receptor protein 3 (NLRP3) inflammasome components (protein as well as RNA levels) and restoration of neuroplasticity markers including brain-derived neurotrophic factor (BDNF) and postsynaptic density protein 95 (PSD95) protein levels. The therapeutic outcome correlated with the dual ability of hydrogen to inhibit pro-inflammatory signaling cascades and protect synaptic structures. These findings suggest that MSN-mediated hydrogen delivery is an effective strategy to address PTSD-associated affective dysfunction by orchestrating neuroimmune responses and synaptic homeostasis.

Indexed as

AnxietyBehavior, AnimalHydrogenInflammasomesNanoparticlesNeuronal PlasticityNLR Family, Pyrin Domain-Containing 3 ProteinStress Disorders, Post-TraumaticAnimalsBrain-Derived Neurotrophic FactorMalePrefrontal CortexRatsRats, Sprague-DawleyBrain-Derived Neurotrophic FactorHydrogenInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratMolecular hydrogenNLRP3 inflammasomePost-traumatic stress disorder (PTSD)Synaptic plasticity

Identifiers

PMID41261203

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.