Evidence map›Paper›PMID 41261216›Full record

ArticleThe EMBO journal2026

S-phase PARylation of microprotein RSMC enhances the function of Sororin in sister chromatid cohesion.

Meiqian Jiang, Jiaxin Zhang, Jiankun He, Yu Miao, Linhui Wang, Haitao Zhong, Yingying Gong, Zhen Li, Li-Lin Du, Xingzhi Xu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Meiqian Jiang *Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, 518055, Shenzhen, China.
Jiaxin Zhang *Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, 518055, Shenzhen, China.
Jiankun HeGuangdong Key Laboratory for Genome Stability & Disease Prevention, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, 518055, Shenzhen, China.
Yu MiaoState Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, 100084, Beijing, China.
Linhui WangGuangdong Key Laboratory for Genome Stability & Disease Prevention, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, 518055, Shenzhen, China.
Haitao ZhongGuangdong Key Laboratory for Genome Stability & Disease Prevention, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, 518055, Shenzhen, China.
Yingying GongGuangdong Key Laboratory for Genome Stability & Disease Prevention, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, 518055, Shenzhen, China.
Zhen LiState Key Laboratory of Plant Environmental Resilience, College of Biological Sciences, China Agricultural University, 100193, Beijing, China.ORCID http://orcid.org/0000-0002-4798-4161
Li-Lin DuNational Institute of Biological Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-1028-7397
Xingzhi XuGuangdong Key Laboratory for Genome Stability & Disease Prevention, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, 518055, Shenzhen, China.ORCID http://orcid.org/0000-0002-4459-2082
Chunlai ChenState Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, 100084, Beijing, China.
Alibek YdyrysBiomedical Research Centre, Al-Farabi Kazakh National University, Al-Farabi Avenue 71, Almaty, 050038, Kazakhstan.
Yisui XiaGuangdong Key Laboratory for Genome Stability & Disease Prevention, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, 518055, Shenzhen, China.
Qinhong CaoState Key Laboratory of Plant Environmental Resilience, College of Biological Sciences, China Agricultural University, 100193, Beijing, China.ORCID http://orcid.org/0000-0002-2055-3513
Huiqiang LouGuangdong Key Laboratory for Genome Stability & Disease Prevention, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, 518055, Shenzhen, China. lou@szu.edu.cn.ORCID http://orcid.org/0000-0003-4465-6186
Wenya HouGuangdong Key Laboratory for Genome Stability & Disease Prevention, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, 518055, Shenzhen, China. wenya.hou@szu.edu.cn.ORCID http://orcid.org/0000-0001-7005-3552

Funding

China Postdoctoral Science Foundation ( ) 2024M752102Medical Scientific Research Foundation of Guagndong Province A2024342National Natural Science Foundation of China 2101039National Natural Science Foundation of China 32161133015National Natural Science Foundation of China 32300074National Nature Science Foundation of China 32101039National Nature Science Foundation of China 32161133015National Nature Science Foundation of China 32300074Shenzhen Science and Technology Program JCYJ20240813143001003Shenzhen Science and Technology Program JCYJ20240813143701003Shenzhen Science and Technology Program KQTD20240729102249044Shenzhen Science and Technology Program RCBS20231211090516017SZU Top Ranking Project 860/00000210SZU Top Ranking Project "B&RsacFMS" 868/0000080208
6 · The paper itself

Abstract

Sororin is essential for establishing sister chromatid cohesion concurrently with DNA replication in metazoans. Although acetylation of the cohesin subunit SMC3 by ESCO1/2 is necessary for Sororin recruitment, it is by itself not sufficient. Here, we demonstrate that DNA replication-coupled Poly(ADP-Ribose) Polymerase (PARP) activity is an additional prerequisite in human cells. During normal S-phase, PARP1 PARylates a microprotein encoded by the alternative ORF C11ORF98, which we designate RSMC (28S rRNA/ribosome and Sororin micro-cofactor). This PARylation strengthens the interaction of RSMC with Sororin, enhancing both chromatin recruitment and anti-Wapl activity of Sororin in concert with SMC3 acetylation. Notably, overexpression of RSMC is able to rescue cohesion defects induced by the PARP inhibitor olaparib. These findings highlight understudied microproteins as critical regulators of fundamental cellular processes, such as sister chromatid cohesion.

Indexed as

Adaptor Proteins, Signal TransducingChromatidsPoly (ADP-Ribose) Polymerase-1S PhaseCarrier ProteinsCell Cycle ProteinsChondroitin Sulfate ProteoglycansChromosomal Proteins, Non-HistoneCohesinsDNA ReplicationHeLa CellsHumansNuclear ProteinsProto-Oncogene ProteinsAdaptor Proteins, Signal TransducingCarrier ProteinsCell Cycle ProteinsChondroitin Sulfate ProteoglycansChromosomal Proteins, Non-HistoneCohesinsNuclear ProteinsPARP1 protein, humanPoly (ADP-Ribose) Polymerase-1Proto-Oncogene ProteinsSMC3 protein, humanWAPL protein, humanChromatinCohesinDark ProteomeDNA ReplicationMicroprotein

Identifiers

PMID41261216
PMCPMC12759081

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.