Evidence map›Paper›PMID 41261899›Full record

ArticleThe Libyan journal of medicine2025

Telmisartan targets Nrf2-HO1 axis in MASLD modulating oxidative stress, inflammation, and mitochondrial dysfunction: mechanistic insights.

Sherif A Kamar, Mohamed Ibrahim Attia, Hanadi A Alahmadi, Alhamza Younis Hamza, Nevien Hendawy, Tarek Abd El-Galil, Tarek A Yousef, Abdullah Al-Dakhil, Sara Khedr, Amal H Eissa and 2 more

Abstract read
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In one paragraph

Article in The Libyan journal of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sherif A KamarFaculty of Dentistry, Al-Ahliyya Amman University (AAU), Amman, Jordan.
Mohamed Ibrahim AttiaChemistry Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.
Hanadi A AlahmadiColleges of Health Science and Nursing, Al-Rayan National Colleges, Madinah, Saudi Arabia.
Alhamza Younis HamzaDepartment of Pharmacy Practice, School of Pharmacy, University of Kansas, Kansas, USA.
Nevien HendawyClinical Pharmacology Department, Faculty of Medicine Ain-Shams University, Cairo, Egypt.
Tarek Abd El-GalilAnatomy Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Tarek A YousefChemistry Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.
Abdullah Al-DakhilChemistry Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.
Sara KhedrClinical Pharmacology Department, Faculty of Medicine Ain-Shams University, Cairo, Egypt.
Amal H EissaClinical Pathology Department, Faculty of Medicine, Helwan University, Helwan, Egypt.
Lamiaa M ElabbasyDepartment of Basic Medical Sciences, College of Medicine, Almaarefa University, Dariyah, Saudi Arabia.
Yosra MagdyClinical Pharmacology Department, Faculty of Medicine Ain-Shams University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolically dysfunction-associated steatotic liver disease (MASLD) has emerged as the leading chronic liver disease worldwide, driven primarily by metabolic derangement. The current investigation proposes to elucidate the hepatoprotective mechanisms of telmisartan (TEL) in MASLD. Twenty-four male Wistar rats were allocated to four groups (Control, MASLD, TEL-treated, and MASLD/TEL). Lipid profiles, glycemic markers, liver enzymes, and hepatic markers of oxidative stress (malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), and catalase) were measured. MASLD-associated genes retrieved from GeneCards® were mapped to

Indexed as

NF-E2-Related Factor 2Non-alcoholic Fatty Liver DiseaseOxidative StressTelmisartanAnimalsDisease Models, AnimalHeme Oxygenase (Decyclizing)InflammationLiverMaleMitochondriaRatsRats, WistarHeme Oxygenase (Decyclizing)Hmox1 protein, ratNfe2l2 protein, ratNF-E2-Related Factor 2TelmisartanhepatoprotectiveIL-6inflammationMASLDoxidative stresstelmisartanTNF-α

Identifiers

PMID41261899
PMCPMC12636547

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.