Evidence map›Paper›PMID 41262006›Full record

ArticleClinical pharmacology and therapeutics2026

Reducing the Burden of Interaction Studies in Cancer Patients Using a Stable Isotopically Labeled Microtracer: A Proof-of-Concept Study with Alectinib.

Ma Ida Mohmaed Ali, Lisa T van der Heijden, Matthijs Tibben, Hilde Rosing, Raween Kalicharan, Gerrina Ruiter, Jos H Beijnen, Hinke Huisman-Siebinga, Alwin D R Huitema, Neeltje Steeghs

Abstract read
In one paragraph

Article in Clinical pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ma Ida Mohmaed AliDepartment of Pharmacy & Pharmacology, Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0000-0002-6853-6763
Lisa T van der HeijdenDepartment of Pharmacy & Pharmacology, Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0000-0001-8538-8101
Matthijs TibbenDepartment of Pharmacy & Pharmacology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Hilde RosingDepartment of Pharmacy & Pharmacology, Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0000-0003-3124-692X
Raween KalicharanDepartment of Pharmacy & Pharmacology, Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0000-0002-4815-3853
Gerrina RuiterDepartment of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0009-0003-1668-8559
Jos H BeijnenDepartment of Pharmacy & Pharmacology, Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0000-0003-0118-561X
Hinke Huisman-SiebingaDepartment of Pharmacy & Pharmacology, Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0000-0001-7767-0393
Alwin D R HuitemaDepartment of Pharmacy & Pharmacology, Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0000-0003-1939-4639
Neeltje SteeghsDepartment of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.ORCID 0000-0003-2989-2279

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditional drug-food interaction studies of oral anticancer agents have a high patient burden. A patient-friendly alternative approach to studying food effects could be the use of stable isotopically labeled microtracers. A prospective, single-center, open-label, crossover, food effect study with the microtracer

Indexed as

Antineoplastic AgentsCarbazolesCarcinoma, Non-Small-Cell LungFood-Drug InteractionsLung NeoplasmsPiperidinesProtein Kinase InhibitorsAdministration, OralAdultAgedArea Under CurveBiological AvailabilityCross-Over StudiesFemaleHumansIsotope LabelingalectinibAntineoplastic AgentsCarbazolesPiperidinesProtein Kinase Inhibitors

Identifiers

PMID41262006
PMCPMC12882758

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.