Evidence map›Paper›PMID 41262413›Full record

ArticleBrain communications2025

Cholinergic white matter pathways integrity in prodromal and early manifest Lewy body disease.

Tamir Eisenstein, Karolien Groenewald, Ludo van Hillegondsberg, Falah Al Hajraf, Tanja Zerenner, Michael A Lawton, Yoav Ben-Shlomo, Ludovica Griffanti, Michele T M Hu, Johannes C Klein

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tamir EisensteinOxford Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Headley Way, Headington, Oxford OX3 9DU, UK.
Karolien GroenewaldOxford Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Headley Way, Headington, Oxford OX3 9DU, UK.
Ludo van HillegondsbergOxford Parkinson's Disease Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Headley Way, Headington, Oxford OX3 9DU, UK.
Falah Al HajrafOxford Parkinson's Disease Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Headley Way, Headington, Oxford OX3 9DU, UK.
Tanja ZerennerPopulation Health Sciences, Bristol Medical School, University of Bristol, 5 Tyndall Ave, Bristol BS8 1UD, UK.
Michael A LawtonPopulation Health Sciences, Bristol Medical School, University of Bristol, 5 Tyndall Ave, Bristol BS8 1UD, UK.ORCID https://orcid.org/0000-0002-3419-0354
Yoav Ben-ShlomoPopulation Health Sciences, Bristol Medical School, University of Bristol, 5 Tyndall Ave, Bristol BS8 1UD, UK.ORCID https://orcid.org/0000-0001-6648-3007
Ludovica GriffantiOxford Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Headley Way, Headington, Oxford OX3 9DU, UK.ORCID https://orcid.org/0000-0002-0540-9353
Michele T M HuOxford Parkinson's Disease Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Headley Way, Headington, Oxford OX3 9DU, UK.ORCID https://orcid.org/0000-0001-6382-5841
Johannes C KleinOxford Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Headley Way, Headington, Oxford OX3 9DU, UK.ORCID https://orcid.org/0000-0002-8553-2801

Funding

Wellcome Trust
6 · The paper itself

Abstract

Degeneration of the nucleus basalis of Meynert (NbM), the main cholinergic source to the cerebral cortex, has been demonstrated in advanced stages of Lewy body (LB) disorders. While the lateral and medial white matter pathways connecting the NbM to the cerebral cortex have been shown to be affected in LB patients with dementia, less is known regarding their vulnerability in prodromal and early manifest patients without significant cognitive impairment, and how their integrity relates to disease manifestation and progression. Here, we used diffusion MRI (dMRI) to examine whether changes in the microstructural integrity of the white matter tracts of the NbM are already evident in prodromal LB disease (namely, isolated rapid eye movement sleep behaviour disorder (iRBD),

Indexed as

cholinergiccognitionLewy body diseaseParkinson’sRBD

Identifiers

PMID41262413
PMCPMC12624394

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.