SynthesisFrontiers in medicine2025
Sarcopenia in idiopathic pulmonary fibrosis: an updated systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- DPEP1 promotes pulmonary fibrosis by regulating arachidonic acid metabolism.Journal of thoracic disease · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sarcopenia has frequently been identified as a comorbid condition in numerous diseases, ultimately influencing patient outcomes. Nonetheless, within the context of idiopathic pulmonary fibrosis (IPF), it has received relatively insufficient clinical focus. This systematic review and meta-analysis were conducted to estimate the prevalence of sarcopenia among individuals diagnosed with IPF and to investigate the links between sarcopenia and both pulmonary function and prognosis in this population. Methods: Comprehensive literature searches were carried out in Excerpta Medica Database (Embase), PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Cochrane Library databases up to 7 July 2025, utilizing relevant MeSH terms. Quality evaluation was implemented through the Joanna Briggs Institute (JBI) tool and the Newcastle-Ottawa Scale. To account for heterogeneity across studies, a random-effects model was implemented. Statistical heterogeneity was examined utilizing I Results: In total, 15 studies satisfied the eligibility requirements for inclusion. Findings indicated that sarcopenia was present in 25% of IPF cases. Participants were stratified into subgroups based on factors such as ethnicity, age, and diagnostic standards for sarcopenia to facilitate subgroup meta-analyses. A consistently elevated prevalence of sarcopenia was observed across all subgroup classifications. Furthermore, most parameters used to assess sarcopenia were found to be decreased in IPF individuals, and those with sarcopenia demonstrated impaired pulmonary function, reduced exercise capacity, and an overall worse prognosis. Conclusion: Current evidence supports the notion that sarcopenia is highly prevalent in IPF populations and may be closely linked to pulmonary functional impairment. Therefore, early identification and therapeutic intervention of sarcopenia should be emphasized in individuals with IPF. Moreover, standardized sarcopenia diagnostic criteria and protocols are urgently needed to ensure accurate meta-analysis results and research conclusions. A prospective, multicenter prospective study with inclusion of sex-specific and comorbidity-adjusted analyses should be awaited in the future. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251089889, identifier CRD420251089889.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.