Evidence map›Paper›PMID 41262575›Full record

ArticleACS pharmacology & translational science2025

John W Sherman, Galen C Rask, Bingcong Xiong, E John Tokarsky, Rachel D Dreher, Aran Weinglass, Colin Hayes, Aundrietta Duncan, Eranthie Weerapana, Emily R Theisen

Abstract read
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

John W ShermanCenter for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43215, United States.
Galen C RaskCenter for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43215, United States.
Bingcong XiongDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.
E John TokarskyCenter for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43215, United States.
Rachel D DreherCenter for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43215, United States.
Aran WeinglassCenter for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43215, United States.
Colin HayesCenter for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43215, United States.
Aundrietta DuncanSalarius Pharmaceuticals, Houston, Texas 77021, United States.
Eranthie WeerapanaDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.ORCID https://orcid.org/0000-0002-0835-8301
Emily R TheisenCenter for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43215, United States.ORCID https://orcid.org/0000-0003-2923-1198

Funding

Developing chemical-proteomic tools to investigate cysteine oxidationR35GM134964 · NIGMS · BOSTON COLLEGE · PI WEERAPANA, ERANTHIE · 2020 to 2024
$3.1M
Training Program in Basic and Translational Pediatric Oncology ResearchT32CA269052 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI TIMOTHY P CRIPE · 2022 to 2026
$1.8M
NCI NIH HHS T32 CA269052NIGMS NIH HHS R35 GM134964
6 · The paper itself

Abstract

The noncompetitive lysine-specific demethylase 1 (LSD1) inhibitors SP-2509 and SP-2577 are

Indexed as

CETSAEwing sarcomairon metabolismiron−sulfur clustermitochondria

Identifiers

PMID41262575
PMCPMC12624487

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.