ArticleInfection and drug resistance2025
Novel LAM Assay Shown Satisfactory Results in the Detection of Tuberculosis.
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Diagnosing tuberculosis (TB) infection remains a challenge for clinicians. According to recommendations from the World Health Organization (WHO), lipoarabinomannan (LAM) testing can be used to diagnose TB infection in individuals. A new generation of urinary LAM testing is now available. However, studies on its accuracy are limited and warrant further exploration. Objective: This study aims to evaluate the accuracy of a new urinary LAM testing using LAM for diagnosing TB infection. Methods: A cross-sectional study was conducted at the Fourth People's Hospital of Nanning, China. Participants were enrolled from December 2023 to May 2024. Fresh urine samples were collected from the participants and tested using LAM. The diagnostic accuracy of the LAM was compared with other tests for Mycobacterium tuberculosis (sputum culture, sputum smear or molecular biology testing). We compared the positive rates of different TB detection methods to evaluate the effectiveness of LAM. In the comparative analysis, the 95% confidence interval was calculated using the Wilson score method. The kappa value was computed, and the corresponding P-value was reported. Results: The positive agreement rate of LAM was 64.37%, the negative agreement rate was 94.29%, and the overall agreement rate was 80.73%. The Kappa value was 0.6013, indicating good consistency between the test reagent and the reference method. Conclusion: LAM can be used for the diagnosis of TB. It provides diagnostic information quickly, easily, and cost-effectively, particularly showing good performance in diagnosing TB.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.